3/21/2017  TCI NEWS

We distribute TCI NEWS every four weeks, to our valued customers using research chemicals and chromatography products. We hope that you find this helpful for your research.

[New Edition] TCIMAIL Quarterly Magazine – No. 173

TCIMAIL contains technical papers contributed by leading professors and scientists. We also introduce our new reagents in the fields of Synthetic Organic Chemistry, Materials Chemistry, Bioscience and Analytical Science. Examples of application and use are explained in an easy way, using various schemes and charts.

Research Article
- Aryl(2,4,6-trimethoxyphenyl)iodonium Salts as Reagents for Metal-Free Arylation of Carbon and Heteroatom Nucleophiles
David R. Stuart
Assistant Professor, Department of Chemistry, Portland State University, United States

Chemistry Chat – Focusing on the Elements –
Naming New Elements
Kentaro Sato

Applications
- High Mobility Organic Semiconductor: 2,6-Diphenylanthracene
- A Novel Hole Transport Material for Perovskite Solar Cells: V886
- Photoremovable DEACM Protecting Group
- Tyrosine Kinase Inhibitor: Methyl 2,5-Dihydroxycinnamate
- Tyrosine Kinase Inhibitor: Tyrphostin AG1478
- Fluorescent Probe: 5-CFDA

[Featured Product] Umemoto's Reagent II -A Powerful Electrophilic Trifluoromethylating Reagent

The trifluoromethyl group has unique properties such as high electronegativity, metabolic stability and lipophilicity. The installment of a trifluoromethyl group is one of the significant functionalizations and is utilized for development in various fields, like pharmaceuticals, agricultural chemicals and material science. Umemoto's Reagent II [D5335] is useful electrophilic trifluoromethylating reagent, and applicable for many reactions under basic conditions such as trifluoromethylation of β-ketoesters at the α-position, direct trifluoromethylation of indoles at the 2-position, and hydroxytrifluoromethylation of styrene derivatives using photoredox catalysts.

Synthetic Organic Chemistry

Research Article

Nitroxyl-radical-catalyzed Oxidative Coupling of Amides with Silylated Nucleophiles

Moriyama et al. have reported the nitroxyl-radical-catalyzed oxidative coupling of amides with silylated nucleophiles. According to their results, in situ generated N-halogenated amides from amides and a halogenation reagent are activated by the treatment of a nitroxyl-radical TEMPO catalyst to afford the corresponding imine intermediates, which further react with silylated nucleophiles giving the desired coupling products in high yields. This reaction opened up new frontiers in nitroxyl-radical-catalyzed reactions, so it is expected that nitroxyl radicals can be used as organocatalysts in various transformations.
T1560

References

Product Highlight

Trifluoromethylthiolating Agent Usable for Direct Dehydroxytrifluoromethylthiolation of Alcohols

Silver(I) trifluoromethanethiolate (1) has already been known as a trifluoromethylthiolating agent1,2) and is also applicable to direct dehydroxytrifluoromethylthiolation.3) 1 successfully gives trifluoromethanethiolate (2) by treatment with tetrabutylammonium iodide (TBAI) or potassium iodide.4) 2 is unstable and is known to decompose into carbonothioic difluoride (3) and fluoride anion. 3 reacts with alcohols to form an intermediate 4. Then, 4 reacts with 2 to afford the corresponding trifluoromethylthiolated product. The trifluoromethylthiolation by using 1 can be applied to alcohols with other functional groups and heterocyclic compounds, so that it is expected to be used in medicinal chemistry.
S0977

References

New Products

Life Science

New Products

HPLC Columns “TCI Chiral series”

Chiral separation of Trichostatic Acid by TCI Chiral BP-S

- A unique stationary phase
  Polymaleimide (helical polymer) bearing chiral side groups coated on silica gel.
- Suitable for separation of carbonyl compounds and the others
  ex. Ketones, Esters, Carboxylic acids, N-Protected Amino acids, Alcohols etc.
- Available for three types chiral stationary phase (MB-S, BP-S and CH-S)
- High column load capacity
- Superior column longevity [Maximum pressure: 2900 psi (20 MPa)]
- Affordable price
Trichostatic Acid

Reagent Guides 8th Edition

In these Reagent Guides, TCI products have been classified according to research fields, reaction types, applications and basic structures. Please click here to contact TCI local distributors or TCI for a Free Copy!
Synthetic Organic Chemistry & Materials Chemistry

Classification examples:

Synthetic Organic Chemistry
Asymmetric Organocatalysts / Cross-coupling Reaction Using Transition Metal Catalysts / Condensation & Active Esterification

Materials Chemistry
Solar Cell Research Reagents / OLED / Photochromic Compounds
Bioscience & Analytical Science

Classification examples:

Bioscience
Nucleosides / Amino Acids / Sugars / Lipids / Terpenes / Steroids / Antibodies

Analytical Science
GC Derivatizing Reagents / HPLC Labeling Reagents / HPLC Columns / Derivatization Reagents for MS

TCI has a wide variety of catalogs and product brochures. Most of them are available in PDF format and can be downloaded from our website.

» Other Catalogs & Product Brochures

TCI Website Tips

Reagent Guide - Online Version Available on TCI Website

TCI Reagent Guides, product catalogs by category, are very useful as reference for finding reagents. Do you know Reagent Guides are also available as online version on our website?
You click “Products” tab, then you can go around our product information by category easily.

Additionally, benefits of online catalogs include;
-New products that aren't included in the paper version are added every day.
-Product categories that aren’t included in the paper version are available, and new categories are uploaded timely.

Please click the following product categories, and find your chemicals!

Exhibitions/Meetings/Shows

253rd ACS National Meeting & Exposition

Moscone Center (Booth #1111)
San Francisco, CA, USA
April 2-6, 2017
» TCI exhibition information      » Event details

The Polymer Society of Korea – 2017 Spring Meeting

Daejeon Convention Center
Daejeon, Korea
April 5-7, 2017
» TCI exhibition information      » Event details

119th KCS General Meeting & Exposition

KINTEX
Goyang, Korea
April 19-21, 2017
» TCI exhibition information      » Event details

Other Information

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