4/18/2017  TCI NEWS

We distribute TCI NEWS every four weeks, to our valued customers using research chemicals and chromatography products. We hope that you find this helpful for your research.

[Featured Product] Novel Fluorescent Probe for Drug-HSA Binding Assay

Investigating whether drugs bind to Human Serum Albumin (HSA) and identifying the drug binding site on HSA are important for pharmacokinetics. BD140 [D4898] is a novel fluorescent probe which binds to HSA drug binding site 2 specifically. BD140 is a powerful tool for drug discovery, R&D and metabolic toxicity assay.

[New Brochure] Hypervalent Iodine Compounds

This contains the list of hypervalent iodine compounds that can be used in various fields such as oxidation, introduction of functional groups, and photo-cationic polymerization initiators.
- Many oxidizing agents that have unique reactivity are listed
- Effective for introduction of various functional groups including Halogenation and Ethynylation

[New Edition] TCIMAIL Quarterly Magazine – No. 173

TCIMAIL contains technical papers contributed by leading professors and scientists. We also introduce our new reagents in the fields of Synthetic Organic Chemistry, Materials Chemistry, Bioscience and Analytical Science. Examples of application and use are explained in an easy way, using various schemes and charts.

Research Article
- Aryl(2,4,6-trimethoxyphenyl)iodonium Salts as Reagents for Metal-Free Arylation of Carbon and Heteroatom Nucleophiles
David R. Stuart
Assistant Professor, Department of Chemistry, Portland State University, United States

Chemistry Chat – Focusing on the Elements –
Naming New Elements
Kentaro Sato

- High Mobility Organic Semiconductor: 2,6-Diphenylanthracene
- A Novel Hole Transport Material for Perovskite Solar Cells: V886
- Photoremovable DEACM Protecting Group
- Tyrosine Kinase Inhibitor: Methyl 2,5-Dihydroxycinnamate
- Tyrosine Kinase Inhibitor: Tyrphostin AG1478
- Fluorescent Probe: 5-CFDA

Synthetic Organic Chemistry

Research Article

Difluoromethylation of Aryl Iodides using a (NHC)Cu(CHF2) Complex

Sanford et al. have reported that difluoromethylations using a (NHC)Cu(CHF2) complex (3) can be prepared/isolated from a copper(I) / N-heterocyclic carbene (NHC) complex of chloro[1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene]copper(I) (1) and (difluoromethyl)trimethylsilane (2). According to their report, previously isolated Cu(I) complex 3 stoichiometrically reacts with various functional group’s substituted aryl iodides and affords the corresponding difluoromethylated compounds in good yield. While, in the presence of cesium fluoride, this reaction can be applied to the catalytic difluoromethylation by the use of catalytic amounts of Cu(I) complex 1 and 2 equivalents of 2 as a difluoromethane source. In general, difluoromethylated copper(I) complex species (“Cu(I)-CHF2”) are considered to be unstable and difficult to isolate. However, this report shows isolation of that Cu(I) species by complexation as a (NHC)Cu(CHF2) complex using a NHC ligand.


Product Highlight

N-Halosaccharins Usable for Halogenations

N-Halosaccharins (X = Cl (1), X = Br (2), X = I (3)) are solid compounds which are easy to handle and can be used as electrophilic halogenating reagents. For example, by treating 1,3-diketone 4 with lithium perchlorate and each halogenating agent, α-halogenated 1,3-diketones are given in high yields. On the other hand, when a high electron-withdrawing difluoroboryl group-coordinated alkoxy borane complex 5 is treated with halogenating agents, halogenations at the 3,5-dimethoxyphenyl moiety of 5 proceed and the related 2,6-dihalogenated compounds are given in high yields and high regioselectivity. In this way, N-halosaccharins can be effectively used for regioselective halogenations of active methylene compounds and aromatic rings.
C1674, B2152, I0784


New Products

Life Science

New Products

Pentafluorophenyl column for HPLC "TCI Stella PFP"

Analysis of cis, trans-isomers by Reversed Phase Columns

TCI Stella PFP

Reagent Guides 8th Edition

In these Reagent Guides, TCI products have been classified according to research fields, reaction types, applications and basic structures. Please click here to contact TCI local distributors or TCI for a Free Copy!
Synthetic Organic Chemistry & Materials Chemistry

Classification examples:

Synthetic Organic Chemistry
Asymmetric Organocatalysts / Cross-coupling Reaction Using Transition Metal Catalysts / Condensation & Active Esterification

Materials Chemistry
Solar Cell Research Reagents / OLED / Photochromic Compounds
Bioscience & Analytical Science

Classification examples:

Nucleosides / Amino Acids / Sugars / Lipids / Terpenes / Steroids / Antibodies

Analytical Science
GC Derivatizing Reagents / HPLC Labeling Reagents / HPLC Columns / Derivatization Reagents for MS

TCI has a wide variety of catalogs and product brochures. Most of them are available in PDF format and can be downloaded from our website.

» Other Catalogs & Product Brochures

TCI Website Tips

Reagent Guide - Online Version Available on TCI Website

TCI Reagent Guides, product catalogs by category, are very useful as reference for finding reagents. Do you know Reagent Guides are also available as online version on our website?
You click “Products” tab, then you can go around our product information by category easily.

Additionally, benefits of online catalogs include;
-New products that aren't included in the paper version are added every day.
-Product categories that aren’t included in the paper version are available, and new categories are uploaded timely.

Please click the following product categories, and find your chemicals!


119th KCS General Meeting & Exposition

Goyang, Korea
April 19-21, 2017
» TCI exhibition information      » Event details

The Pharmaceutical Society of Korea, Division of Medicinal Chemistry - 2017 Medicinal Chemistry Workshop

Daemyung Resort, Goseong, Korea
June 22-23, 2017
» TCI exhibition information      » Event details

RACI Centenary Congress

Ground Floor, Booth No. G35
Melbourne Convention and Exhibition Centre, Australia
July 23-28, 2017
» TCI exhibition information      » Event details

Other Information

TCI Facebook Page

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