Phosphorylating and phosphorothioating agents, condensing, and protecting agents for hydroxy and amino groups are of importance in the synthesis of nucleic acid (DNA/RNA) chains. Through direct action on gene expression and pathogenic proteins, these medicines hold great promise for treating diseases that were formerly difficult to treat. TCI offers 2-cyanoethyl N,N,N',N'-tetraisopropylphosphordiamidite [C2228] for the for phosphitylation, and xanthane hydride [X0001] for synthesis of oligonucleotide phosphorothioates.
Carbon Nanobelts are the ultimate seeds and have the reputation of being "dream molecules" for their influence in everything from from nanomachines to single-molecule electronics and photonics. After 60 years of painstaking synthetic challenges, TCI now offers (6,6)carbon nanobelt [I1078]. Amazing properties include having a rigid belt structure with 12 fully fused benzene rings, a partial structure of armchair-type carbon nanotube (CNT), and more.
Copper/photoredox-catalyzed Decarboxylative sp3 C–N Coupling Reaction of N-Heteroaromatics
MacMillan and co-workers have recently synergistically utilized CuTC (= copper(I) 2-thiophenecarboxylate) [C2312] as a catalyst for a C-N coupling reaction of N-heteroaromatic derivatives in the presence of photoredox catalyst. For example, iodomesitylene dicarboxylate prepared from iodomesitylene diacetate and alkyl carboxylic acids reacts with N-heteroaromatic derivatives. The Ir complex, CuTC and bathophenanthroline [D0905] act as a catalyst to give the corresponding N-alkyl heteroaromatic products in good yields.
TCIMAIL Research Article: Carbocyclization of Carbohydrates to Hydroxylated Cycloalka(e)nes
In the recently released TCIMAIL, we feature Professor Tony K. M. Shing's resarch article, "Carbocyclization of Carbohydrates to Hydroxylated Cycloalka(e)nes". For roughly 30 years, his research focus has been on the carbocyclization of carbohydrates with the conversion of simple, readily available monosaccharides into hydroxylated cycloalkanes and cycloalkenes with pharmaceutical potential.
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