Developed as an alternative to N-Heterocyclic carbenes (NHCs) and behaving as a strong σ donor, Cyclic alkyl amino carbenes (CAACs) are NHC analogs with an electron-rich carbon atom substituting a nitrogen atom. CAACs are also excellent ligands for transition metal complexes as well as typical metals and boron compounds. With unique reactivity of these complexes reported, TCI offers Cyclohexyl-CAAC [D5596] as a CAAC precursor.
Used in organic synthesis as both a reagent and solvent, Sulfur dioxide (SO2) though gaseous, is highly toxic and more costly to use. Labs looking for SO2 surrogate reagents turn to TCI for DABSO [B3960] and Potassium Disulfite [P2480] (both solids), and TIMSO [U0113] (liquid). An example of using DABSO [B3960] as an alternative SO2 source, includes using the copper-catalyzed direct sulfonylative-Suzuki coupling of aryl boronic acids with electrophiles. Furthermore, it has been reported that the reactions using these reagents affords sulfones, sulfonylfluorides, sulfonamides, sulfinates and sulfoxides.
Interrupted Carbonyl-Olefin Metathesis via Oxygen Atom Transfer
The Schindler Group recently discovered an additional mechanistic pathway involving a key oxetane intermediate through the synthesis of a variety of tetrahydrofluorenes. The synthesis of tetrahydrofluorenes via this method employs triflic acid [T0751] as the acid catalyst and features a broad substrate scope varying from good to excellent yield. The aromatic moiety is tolerant to strongly electron donating, electron withdrawing, and heteroaromatic (e.g. thiophene) groups.
The basic components for organic synthesis, TCI offers a market-leading building blocks including functionalized heterocycles, carbonyl compounds, halogenated compounds, fluorinated compounds and more. Above are 3 new heterocyclic building blocks for your research.
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