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The demand for better medicines, advances in technology, and protecting the food we consume all have one tool in common that has overwhelmingly improved the ability of chemists to placate these demands: Heck, Negishi, and Suzuki coupling reactions. This issue covers TCI’s chemistry expertise in palladium catalysts for cross-coupling, trifluoroborate salts for Suzuki-Miyaura reactions, oxidative cross-coupling trifluoromethylation reagents via oxidative cross coupling, and how enol tosylate for cross-coupling reaction can help your research.
Palladium Catalysts
Palladium Catalysts for Cross-coupling Reaction
Organopalladium complexes generally show lower reactivity compared to those of organonickel complexes. However, their chemical stability against oxidation make organopalladium complexes easier to handle and are the preferred reagents for cross-coupling reactions. See how TCI’s tetrakis(triphenylphosphine)palladium(0) [T1350], widely used as a catalyst for palladium-catalyzed coupling reactions, can help make your reactions more stable and safe.
Learn more about Pd Complexes
Trifluoroborate Salts
Direct Introduction of Hydroxymethyl- and
Aminomethyl-Groups via stable Trifluoroborate Salts

Commonly used as reactants for Suzuki-Miyaura cross-coupling reactions, organoboronic acids, specifically aryl boronic acids and alkenyl boronic acids, are chemically stable and easy to treat. For such purposes, TCI offers organotrifluoroborate salts that include potassium (methoxymethyl)trifluoroborate [P2153], potassium (acetoxymethyl)trifluoroborate [P2494], potassium (phthalimidomethyl)trifluoroborate [P2514], and potassium (N-Boc-aminomethyl)trifluoroborate [P2155] to allow for more electrically and chemically stable reactions.
See TCI's Trifluoroborate Salts
Copper Complexes for Trifluoromethylation
Copper Complexes for Trifluoromethylation via Oxidative Cross-coupling
Trifluoromethylated aromatic compounds are important intermediates for the synthesis of pharmaceuticals, agrochemicals, and polymer materials. For trifluoromethylation, TCI offers Cu-based reagents (1,10-phenanthroline)(trifluoromethyl)(triphenylphosphine)copper(I) [P2172] and (trifluoromethyl)tris(triphenylphosphine)copper(I) [T2883] which are air-stable crystalline solids, safe, and has also been reported to successfully trifluoromethylate various aryl iodides in good yields.
See Cu-Complexes for Trifluoromethylation
Enol Tosylate for Stereoretentive Cross Coupling Reactions
Enol Tosylate for Stereoretentive Cross Coupling Reactions
Utilized as a building block, methyl (Z)-3-(p-toluenesulfonyloxy)but-2-enoate [M3043] features an enol tosylate moiety and is used for stereoselective cross coupling reactions. The treatment of methyl (Z)-3-(p-toluenesulfonyloxy)but-2-enoate [M3043] under either the Negishi or Sonogoshira conditions affords coupled products substituted at the tosyl position. This reaction has the advantage of stereoretentively proceeding of alkene moiety.
See TCI Enol Tosylate

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