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TCI offers a wide selection of fine and specialty chemicals by drawing upon expert manufacturing techniques. With an extensive catalog of 29,000 high quality organic reagents suitable for benchtop-to-bulk chemistry. This issue features our bench-stable fluoroalkylating agents, a useful catalyst for Balz-Schiemann fluorination, our TCIMAIL Research Article on Asymmetric Synthesis of Axially Chiral Compounds by Rhodium(I)-Catalyzed [2+2+2] Cycloaddition, and more.
Bench-stable Crystalline Fluoroalkylating Agents

Bench-stable Crystalline Fluoroalkylating Agents

Sulfonium salts are useful reagents for fluoroalkylation. The trifluoromethylating agent (Umemoto's Reagent II) [D5335] affords trifluoromethylated products from various substrates. The difluoromethylating agent [D5630] is suitable for metal-free photoredox-catalyzed difluorometylation. Additionally, these solid reagents are bench-stable and easy-to-handle.
Read More on S-(Fluoroalkyl)sulfonium Salts
Balts-Schiemann Fluorination

Hypervalent Iodine-Catalyzed Balz–Schiemann Fluorination

1-Fluoro-3,3-dimethyl-1,2-benziodoxole [F0957] is a useful catalyst for Balz?Schiemann reactions. In the presence of catalytic amount of [F0957] and BF3·OEt2 [B0527], aryl diazonium tetrafluoroborate salts react at r.t. - 60 °C to afford the corresponding fluorinated aryl products in good yields. This reaction can proceed at a lower temperature than conventional Balz-Schiemann reactions and is applicable to various compounds bearing electron-withdrawing groups such as esters, as well as heteroarenes.
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TCIMAIL and Our 50th Anniversary Issue

TCIMAIL is turning 50! TCIMAIL contains technical papers contributed by leading professors and scientists featuring TCI products. We invite you to read back issues that contain various scientific articles from prominent researchers. Be on the lookout for our 50th Anniversary issue coming in 2019!
TCIMAIL Research Article

TCIMAIL Research Article: Asymmetric Synthesis of Axially Chiral Compounds by Rhodium(I)-Catalyzed [2+2+2] Cycloaddition

In the recently released TCIMAIL, we feature Professor Ken Tanaka's resarch article, "Asymmetric Synthesis of Axially Chiral Compounds by Rhodium(I)-Catalyzed [2+2+2] Cycloaddition." The use of cationic rhodium(I)/axially biaryl bisphosphine complexes as catalysts allows for the highly efficient enantioselective biaryl synthesis to occur. Also discussed is the enantioselective synthesis of axially chiral compounds with non-biaryl axial chirality and the diastereoselective biaryl synthesis.
Read the Full Article

Upcoming Event

TCI Conference Report

The ceremony of “TCI Organic Synthesis Award”, December 2018 in Taiwan

The Second “TCI Organic Synthesis Award” ceremony was held at the Chinese Chemical Society Located in Taipei (CCS Taipei) annual meeting in Taiwan on December 8, 2018. This award is established by TCI together with CCS Taipei and is given to the student in organic synthesis research field who is chosen as the winner in the graduate student thesis competition (includes dissertation and academic study achievements) of the CCS Taipei annual meeting.
TCI will keep on supporting researchers to contribute the development of science.
Right: Award-winner, Mr. Yu-Fu Liang (Department of Chemistry, National Tsing Hua University)
Left: Presenter, Mr. Hiromichi Sugahara (Executive Director, TCI)
Award-winning paper title:
Synthesis of Functionalized Pyroglutamate and their Application in Synthesis of Natural Products

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