Welcome to TCI
New inventions and improvements of existing tools for organic chemistry, like our new supramolecular gelators, make it possible to quickly and efficiently create intricate molecules from basic starting materials. In this issue, we highlight three new TCI reagents for peptide synthesisorganocatalysts for asymmetric reactions, Weinreb amides, and more.
Supramolecular-gel Gelators for Recrystallization and Polymorph Control

Supramolecular-gel Gelators for Recrystallization and Polymorph Control

Composed of two nitrophenylurea moieties via a carbon tether moiety, our compounds [M3072] and [H1655], are utilized as supramolecular gelators. When a small amount of the gelator is dissolved in organic solvents, it prodcues robust gels while simultaneously binding with dissolved compounds. Supramolecular gel-phase crystallization offers an extremely versatile new tool in pharmaceutical polymorph screening.
More on Supramolecular-gel Gelators

New Products for Peptide Synthesis

Amino acids and their N-protected derivatives, such as Boc- and Fmoc-amino acids, are essential for peptide synthesis. In addition to our new products [B5887], [C3382], and [F1193], click below to see TCI's full selection of reagents for peptide synthesis.
See TCI Peptide Synthesis Reagents
Organocatalysts for Asymmetric Michael Additional Reactions

Organocatalysts for Asymmetric Michael Additional Reactions

Our two prolinol derivatives, (R)-(+)-α,α-diphenyl-2-pyrrolidinemethanol trimethylsilyl ether [D3867] and (S)-(-)-α,α-diphenyl-2-pyrrolidinemethanol trimethylsilyl ether [D3843], also commonly known as Hayashi-Jørgensen catalysts, are used in various types of asymmetric reactions. Recently, Hayashi et al.reported an asymmetric Michael addition of nitroalkenes and aldehydes, gave syn adducts with high enantio- and diastereoselectivities. Furthermore, when utilizing this reaction as a key early-stage step, it also allowed the team to achieve short synthesis of the anti-flu drug oseltamivir phosphate.
Read More on Our Prolinol Derivatives
Weinreb Amides

An Effective Method for Ketone Synthesis

Weinreb and Nahm published in 1981 a very useful method for the ketone synthesis. N-methoxy-N-methylamides, now popularly called Weinreb amides can be used for the synthesis of ketones with organolithium and Grignard reagents. TCI offers a variety of Weinreb amides like [M0919] or [T3326] for clean and effective ketone synthesis.
See TCI´s Variety of Weinreb Amides
TCI Bulk Chemicals

TCI Bulk Chemicals

If you're in need of critical raw materials in your supply chain or have a large scale production project, TCI can help! We offer a clear pathway to success and a designated point of contact, as well as regularly solicit feedback to ensure specifications and expectations are being met. See why companies turn to TCI for their bulk solutions!
Start Your Bulk Quote

Upcoming Events

The Polymer Society of Korea 2019 Spring Meeting
April 10 - 12, 2019
Busan, Korea

April 16 - 19, 2019
Goyang, Korea

123rd General Meeting of the Korean Chemical Society
April 17 - 19, 2019
Suwon Convention Center
Suwon, Korea

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