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At TCI, we support discovery in life sciences through our knowledge and expertise in organic small molecules. In this issue, we focus on our labeled core-fucosylated N-glycans, xylem differentiation agents, BET bromodomain inhibitor, and more. We also have thousands of other useful compounds available only at TCI for your research and development.
Labeled Core-fucosylated N-Glycans

Labeled Core-fucosylated N-Glycans

Core-fucosylated N-glycans refer to human type N-glycans (G0, uniform isomers 3-G1 and 6-G1, and G2) with a core fucose bound to a position 6 of the reducing terminal β-N-acetylglucosamine. TCI offers high-grade 2-AB labeled core-fucosylated N-glycans by chemical synthesis technology. Take full advantage of our fluorescent-labeled products as a standard glycan for MS, CE, and HPLC analyses of biopharmaceuticals including antibody drugs.
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Xylemin - (a Polyamine Inducing Xylem Differentiation) and Synthetic Proauxin

Xylemin - (a Polyamine Inducing Xylem Differentiation) and Synthetic Proauxin

Xylemin dihydrochloride [X0080], a polyamine whose unique function was reported by Takahashi and Motose et al., promotes xylem differentiation with a synthetic proauxin (2,4-D IOE) [O0518] by the inhibition of biosynthesis of thermospermine, which suppresses xylem differentiation. X0080 is anticipated to be used in the research and development of agrochemicals and biomass energy.
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Potent BET Bromodomain Inhibitor

Potent BET Bromodomain Inhibitor

OTX 015 [O0482] is a potent inhibitor of BET (bromodomain and extra-terminal motif) bromodomain proteins including BRD2, BRD3, and BRD4. BET bromodomain protein, called “reader” in epigenetics, recognizes acetylated lysines in histones and regulates chromatin remodeling and transcription. Inhibition of these functions by OTX 015 decreases expression of an oncogene product MYC and negatively regulates signaling pathways of TLR, JAK/STAT, and important factors of immune response like NF-κB. So, OTX 015 is valuable for cancer and immune/inflammatory research.
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Terpenes

Terpenes

Terpenes are a large family of natural products and are known to be the primary constituents of essential oils. They are biosynthesized via the mevalonate pathway. The basic structure is derived from five-carbon isoprene units which are linked together in a head-to-tail fashion to form linear chains or rings. TCI offers terpene products listed in order of chemical structure, such as hemiterpenes, acyclic monoterpenes, sesquiterpenes, diterpenes, and triterpenes.
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