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FGFR/VEGFR Tyrosine Kinase Inhibitor

No.177(April 2018)
PD173074  (1)
PD173074 (1) inhibits the tyrosine kinase activities of the fibroblast growth factor receptor (FGFR) and vascular endothelial growth factor receptor (VEGFR) (Table 1).1) The inhibitory manner of 1 is ATP-competitive and the inhibitory constants (Ki) of 1 to FGFR1 and its cytoplasmic domain are 45.2±4.8 nM and 36.4±3.6 nM, respectively.
1 also inhibits the differentiation of mouse and human embryo stem cells2,3) and human induced pluripotent stem cells.4)

Table 1. Inhibitory activity of PD173074


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