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Glycoamino Acid

Glycoamino Acid 1 consists of glucose and asparagine, and Inazu and his coworkers has reported an excellent synthetic method for this compound in recent years.1) 1 can be utilized for the syntheses of N-(asparagine-linked) glycoprotein and glycopeptides. For example, 1 reacts with peptides 2 supported by silica gel to produce glycopeptides 3. In addition, the resulting 3 can be reacted with N-acetylglucosamine or oligosaccharides by using glycosyltransferase making the sugar chain elongation possible.2)


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