Home > Exhibitions / Brochures Download > Quarterly Printed Magazine "TCIMAIL" > BackNumbers 2007 > α-Homonojirimycin


No.125(March 2007)
α-Homonojirimycin (1) is an aza-sugar, whose oxygen atom within the monosaccharide ring is replaced with an imino moiety; it has been shown to significantly affect sugar chain processing in vivo. 1 is an excellent glycosidase inhibitor. The mechanism for its inhibition has been explained as that a glutamic acid or asparagine residue of the glycosidase forms an ionic bond with an imino moiety of the aza-sugar.1) Moreover, 1 is also used as a leading compound of effective agents for the treatment of Fabry disease (disease causing a glyco sphingolipid lysosomal storage disorder), which is caused by an active enzyme deficiency (α-galactosidase A).2)


The prices are subject to change without notice. Please confirm the newest price by our online catalog before placing an order.
In addition, sales products changes with areas. Please understand that a product is not available when the product details page is not displayed.