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Synthesis of Optically Active α-Arylglycine Derivatives

Iminolactone 1 is stereoselectively added to various phenols, anilines and arylboronic acids to give an optically active morpholine derivative, like 2. The compound 2 is then subjected to ring-opening, protection and de-protection to give optically active alpha-arylglycine derivative, like 3.

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