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Phosphodiesterase 7 Inhibitor

No.177(April 2018)
BRL 50481  (1)
BRL 50481 (1) is a selective inhibitor of phosphodiesterase 7 (PDE7).1) 1 inhibits human recombinant PDE7 in a competitive manner (Ki = 180 nM). 1 is much less potent against PDE3 and PDE4 (Table 1). In addition, treatment of human mesenchymal stem cell-derived osteoblasts with 1 increased mineralization.2)

Table 1. Selectivity of BRL 50481 (1) to PDE isoenzymes1)


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