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Cyclooxygenase (COX) Inhibitor: Flurbiprofen

No.178(July 2018)
Flurbiprofen  (1)
Flurbiprofen (1) functions as a cyclooxygenase (COX) inhibitors and inhibits COX-1 and COX-2 with the IC50s of 0.1 μM and 0.4 μM, respectively.1) 1 exists as a racemic mixture of their enantiomeric form and the S-isomer is a more potent inhibitor of COX isoenzymes than the R-isomer.2,3) 1 is also widely known as a non-steroidal anti-inflammatory drug (NSAID).1) Furthermore, 1 maintains the self-renewal and pluripotency of human embryonic stem cells.4,5)
* Human recombinant COX-1 and COX-2 were used in the reference 1.

This product is for research purpose only.


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