Home > Products > DABSO, TrNSO: Reagents for One-Pot Synthesis of Sulfonamides and Sulfonimidamides
Sulfonamide is an increasingly prominent functional group found in many drugs and drug candidates. Whereas, sulfonimidamide has recently garnered attention as a bioisostere of carboxylic acid and sulfonamide. Both, DABSO and TrNSO are convenient reagents for the one-pot syntheses of sulfonamide/sulfonimidamide compounds from Grignard reagents.
Products
Advantages
• Reacts with Grignard reagents and amines to give sulfonamides or sulfonimidamides, respectively
Applications
Synthesis of sulfonamides using DABSO 1)
Synthesis of sulfonimidamides using TrNSO 2)
References
- 1)DABCO-Bis(sulfur dioxide), DABSO, as a Convenient Source of Sulfur Dioxide for Organic Synthesis: Utility in Sulfonamide and Sulfamide Preparations
- 2)One-Pot, Three-Component Sulfonimidamide Synthesis Exploiting the Sulfinylamine Reagent N-Sulfinyltritylamine, TrNSO
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