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DABSO, TrNSO: Reagents for One-Pot Synthesis of Sulfonamides and Sulfonimidamides

Sulfonamide is an increasingly prominent functional group found in many drugs and drug candidates. Whereas, sulfonimidamide has recently garnered attention as a bioisostere of carboxylic acid and sulfonamide. Both, DABSO and TrNSO are convenient reagents for the one-pot syntheses of sulfonamide/sulfonimidamide compounds from Grignard reagents.

B3960,T3773

Products

Advantages

• Easy-handleable stable solid
• Reacts with Grignard reagents and amines to give sulfonamides or sulfonimidamides, respectively

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Applications

Synthesis of sulfonamides using DABSO 1)

Synthesis of sulfonamides using DABSO

Synthesis of sulfonimidamides using TrNSO 2)

Synthesis of sulfonimidamides using TrNSO

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References

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