Home > Exhibitions / Brochures Download > Quarterly Printed Magazine "TCIMAIL" > Back Numbers > Sodium Dispersion Applicable to Organic Synthesis

Sodium Dispersion Applicable to Organic Synthesis

Sodium dispersions including SD Super Fine™ (1) have been used for the dechlorination of polychlorobiphenyls (PCBs) within industry. In recent years, many its application to organic synthesis such as Bouveault−Blanc reductions1) and the reduction of tertiary amides2) have been reported. For instance, Takai et al. reported a simple preparation of organosodium compounds from organic chlorides and 1 for cross-coupling reactions.3) Organosodium compounds transmetallate with boron and zinc reagents to form organozinc and organoboron intermediates respectively. These intermediates can be readily applied to Negishi and Suzuki-Miyaura cross-coupling in the one-pot manner. In addition, the direct cross-coupling of arylsodiums and arylhalides can be achieved (Scheme 1). Takai et al. also developed lithium-free preparations of NaTMP (2) using 1 via method A and method B (Scheme 2).4) 2 has proven to be effective for Wittig reactions, double-bond isomerizations, and functionalization of heteroarenes. In addition, Mori et al. have reported the preparation of anhydrous solvents using 1 as a dehydrating agent.5) Owing to its large surface area, less reagent and time is required for dehydration, as well as a simplified quenching compared to large sodium lumps.
Preparation of organosodium compounds using D5792 and its application to cross-cou
Scheme 1 Preparation of organosodium compounds using 1 and its application to cross-coupling reactions
Preparation of NaTMP using D5792
Scheme 2 Preparation of NaTMP using 1
*This product was commercialized with the cooperation and help from Kobelco Eco-Solutions Co., Ltd.
*Our items are distributed in accordance with local chemical regulations. Please note that some items are unavailable in some areas.


The prices are subject to change without notice. Please confirm the newest price by our online catalog before placing an order.
In addition, sales products changes with areas. Please understand that a product is not available when the product details page is not displayed.