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Tetroses Rarely Existing in Nature

D-Erythrose (1) and D-threose (2) are rare sugars, monosaccharides (with 4 carbon atoms) found only in small amounts in nature. In plants and microorganisms, 1 is converted to D-erythrose-4-phosphate (4EP) by phosphorylation and then used in heptose phosphate pathway or shikimate biosynthesis pathway.1) Moreover, 1 has proved to an inhibitor of tumor cell growth.2) It has been reported that 2 suppresses mannitol dehydrogenase.3)


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