Home > Products > Name Reactions by TCI > Corey-Fuchs Reaction

Corey-Fuchs Reaction

 The Corey-Fuchs reaction is a two-step reaction sequence used to convert aldehydes into terminal alkynes. The intermediate 1,1-dibromoalkene is produced from aldehydes, triphenylphosphine and carbon tetrabromide during the reaction sequence and can be isolated. This is then converted to the alkyne following the addition of a strong base such as butyllithium.



Reagents: carbon tetrabromide, triphenylphosphine, butyllithium
Reactants: aldehydes
Products: terminal alkynes

Scheme:

Corey-Fuchs reaction

Original literature

Review literature