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Williamson ether synthesis

 The Williamson ether synthesis is an old, but still frequently encountered organic reaction, which provides ether products most often from alcohols and alkyl halides. Alkoxides, derived from alcohols and bases such as sodium hydride or generated in situ, and alkyl halides can react through SN2 type mechanisms to give a variety of ether products. The reactivity is generally dependent on reaction the scope of the pertinent SN2 reaction, with sterics being the dominant presiding factor.



Reagents: alcohols, alkoxides
Reactants: alkyl halides
Products: ethers

Scheme:

Williamson ether synthesis Reaction

Original literature

Review literature