Home > Exhibitions / Brochures Download > Quarterly Printed Magazine "TCIMAIL" > BackNumbers 2008 > Optical Resolution for Alcohols and Thiols

Optical Resolution for Alcohols and Thiols

Compound 1, developed by Nemoto et al., is an optical resolving agent for alcohols and thiols. Using this reagent under a simple protocol, chiral alcohols and thiols can be easily obtained with high optical purity. For example, 1 reacts with racemic alcohols in benzene or dichloromethane in the presence of an acid catalyst to form a mixture of diastereomers 2. These diastereomers can then be separated on the thin layer chromatography (TLC), and easily isolated by silica gel column chromatography. Methanolysis of the isolated compounds 2 in the presence of an acid catalyst affords the chiral alcohols. Moreover, it is possible to recover 3 and reuse 1 derived from 3. Since this process proceeded under a mild condition, it has been expected to be a useful method to obtain chiral alcohols and thiols.


The prices are subject to change without notice. Please confirm the newest price by our online catalog before placing an order.
In addition, sales products changes with areas. Please understand that a product is not available when the product details page is not displayed.