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SIRT1 and 2 Inhibitor

No.181(August 2019)
Cambinol  (1)
Cambinol (1) is a cell-permeable inhibitor of sirtuin (SIRT) 1 and 2.1) The IC50 values to NAD-dependent deacetylation of acetyl-histone H4 peptide are 56 µM and 59 µM for SIRT1 and SIRT2, respectively. The inhibition manners are competitive for the substrate peptide and non-competitive for NAD. 1 also is inhibits sphingomyelinase 2 with Ki value of 7 µM.2) The inhibition manner is uncompetitive.
1 is also known as NSC 112546.


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