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The helioxanthin analogue (TH) is an osteogenic small compound that was first reported by Ohba et al.1) In their reports, TH not only stimulates osteoblast differentiation of osteoblast precursors, but also enhances bone regeneration in rodent bone defect models.2,3) The osteogenic effects are also observed in mouse and human pluripotent stem cells4,5) as well as human dental pulp stem cells.6)
Advantages
• Enhances bone regeneration in rodent bone defect models
• Induces the osteogenic effects on stem cells
Applications
Figure 1. mRNA expression of osteoblast marker genes
in MC3T3-E1 cells treated with TH for 14 days (RT-qPCR analysis).
Figure 2. ALP staining of MC3T3-E1 cells treated with TH for 14 days.
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References
- 1)A novel osteogenic helioxanthin-derivative acts in a BMP-dependent manner
- 2)Enhancement of bone formation ex vivo and in vivo by a helioxanthin-derivative
- 3)Bone healing by sterilizable calcium phosphate tetrapods eluting osteogenic molecules
- 4)Stepwise Differentiation of Pluripotent Stem Cells into Osteoblasts Using Four Small Molecules under Serum-free and Feeder-free Conditions
- 5)Three-dimensional system enabling the maintenance and directed differentiation of pluripotent stem cells under defined conditions
- 6)Bone regeneration by human dental pulp stem cells using a helioxanthin derivative and cell-sheet technology
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