10/07/2013  TCI eNewsletter

Dear Valued Customers.

We really appreciate your great support for TCI - your reagent partner.

We proudly announce that we will start sending our TCI eNewsletter to our valued customers based in Singapore today October 7, 2013. This eNewsletter will be send to you every four weeks. This would be the useful and essential information source to support your research.

We appreciate your continuous support for TCI.

Sincerely yours,

Synthetic Organic Chemistry

Product Highlight

Novel Selective Iodinating Reagent

N,N-Dimethyl-N-(methylsulfanylmethylene)ammonium iodide developed by Porter et al. is a novel selective iodinating reagent, which can convert primary and secondary alcohols to the corresponding iodo compounds. In particular, primary alcohols react more rapidly than secondary alcohols, which allows selective iodination of primary hydroxy groups or in primary-secondary diols.


A. R. Ellwood, M. J. Porter, J. Org. Chem. 2009, 74, 7982.

New Products


Research Article

HDAC2 may be a New Target for Schizophrenia Treatment

Kurita et al. have reported chronic treatment with atypical antipsychotic drugs (clozapine and risperidone) decreases expression of metabotropic glutamate 2 receptor (mGlu2, also known as Grm2), restrains the therapeutic effects of atypical antipsychotic drugs, and acetylates histone at its promoter gene in the mouse and human frontal cortex. They have also shown that additional treatment with SAHA as a histone deacetylase (HDAC) inhibitor prevents this decrease in mGlu2, and augments the behavioral effects of atypical antipsychotics drugs. These data suggest that HDAC2 may be a new therapeutic target to augment the treatment of schizophrenia. (Notice that these products are for research purpose only.)
C2547, R0087, H1388


M. Kurita, T. Holloway, A. García-Bea, A. Kozlenkov, A. K. Friedman, J. L. Moreno, M. Heshmati, S. A. Golden, P. J. Kennedy, N. Takahashi, D. M. Dietz, G. Mocci, A. M. Gabilondo, J. Hanks, A. Umali, L. F. Callado, A. L. Gallitano, R. L. Neve, L. Shen, J. D. Buxbaum, M.-H. Han, E. J. Nestler, J. J. Meana, S. J. Russo, J. González-Maeso, Nat. Neurosci. 2012, 15, 1245.

New Products

Other Information

TCI website - New drawing editor "JSME" for easier structure search

Drawing editor was upgraded for easier structure search.
  - Fast start-up
  - No Java update necessary
  - Works smoothly on Mac
  - Works on tablet device

 Enhanced features

  - Drawn structure can be copied as SMILES and MOL format
     by right click.
  - REDO function is available.
  - Drawing spiro ring is easy with "spiro" function.
  - Functional group can be selected easily from pop-up

» Click here to start Structure Search with JSME

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Tee Hai Chem Pte. Ltd.

18 Tuas Link 1, Tee Hai Building, Singapore 638599
Tel: +65-68625655
Fax: +65-68625855

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