10/07/2013  TCI eNewsletter

Dear Valued Customers.

We really appreciate your great support for TCI - your reagent partner.

We proudly announce that we will start sending our TCI eNewsletter to our valued customers based in Singapore today October 7, 2013. This eNewsletter will be send to you every four weeks. This would be the useful and essential information source to support your research.

We appreciate your continuous support for TCI.

Sincerely yours,

Synthetic Organic Chemistry

Product Highlight

Novel Selective Iodinating Reagent

N,N-Dimethyl-N-(methylsulfanylmethylene)ammonium iodide developed by Porter et al. is a novel selective iodinating reagent, which can convert primary and secondary alcohols to the corresponding iodo compounds. In particular, primary alcohols react more rapidly than secondary alcohols, which allows selective iodination of primary hydroxy groups or in primary-secondary diols.
D4340

References

A. R. Ellwood, M. J. Porter, J. Org. Chem. 2009, 74, 7982.

New Products

Bioscience

Research Article

HDAC2 may be a New Target for Schizophrenia Treatment

Kurita et al. have reported chronic treatment with atypical antipsychotic drugs (clozapine and risperidone) decreases expression of metabotropic glutamate 2 receptor (mGlu2, also known as Grm2), restrains the therapeutic effects of atypical antipsychotic drugs, and acetylates histone at its promoter gene in the mouse and human frontal cortex. They have also shown that additional treatment with SAHA as a histone deacetylase (HDAC) inhibitor prevents this decrease in mGlu2, and augments the behavioral effects of atypical antipsychotics drugs. These data suggest that HDAC2 may be a new therapeutic target to augment the treatment of schizophrenia. (Notice that these products are for research purpose only.)
C2547, R0087, H1388

References

M. Kurita, T. Holloway, A. García-Bea, A. Kozlenkov, A. K. Friedman, J. L. Moreno, M. Heshmati, S. A. Golden, P. J. Kennedy, N. Takahashi, D. M. Dietz, G. Mocci, A. M. Gabilondo, J. Hanks, A. Umali, L. F. Callado, A. L. Gallitano, R. L. Neve, L. Shen, J. D. Buxbaum, M.-H. Han, E. J. Nestler, J. J. Meana, S. J. Russo, J. González-Maeso, Nat. Neurosci. 2012, 15, 1245.

New Products

Other Information

TCI website - New drawing editor "JSME" for easier structure search

JSME
Drawing editor was upgraded for easier structure search.
  - Fast start-up
  - No Java update necessary
  - Works smoothly on Mac
  - Works on tablet device

 Enhanced features

  - Drawn structure can be copied as SMILES and MOL format
     by right click.
  - REDO function is available.
  - Drawing spiro ring is easy with "spiro" function.
  - Functional group can be selected easily from pop-up
     menu.

» Click here to start Structure Search with JSME

TCI Facebook Page

Various information, news, and fun contents are posted constantly for you. Visit us and like us on Facebook!

https://www.facebook.com/TCIchemicals

TCI's Distributor in Singapore

Do you want to buy TCI reagents? Please contact our distributor in Singapore, Tee Hai Chem Pte. Ltd.

Tee Hai Chem Pte. Ltd.

18 Tuas Link 1, Tee Hai Building, Singapore 638599
Tel: +65-68625655
Fax: +65-68625855

TCI has sent this enewsletter to you at the following address:
<{!Lead.Email}>

This enewsletter is delivered to our customers who request TCI's information or exchange business cards, etc.
Please check the following information about how to change delivery address and unsubscribe the enewsletter.
It will take some time to complete changing your status. Thank you for your patience and understanding.

●MyTCI Member
Please log in to MyTCI and edit your account information. "Edit Your Account Infomration" button is in the upper right in MyTCI page.

» Log in to MyTCI

●non-MyTCI Member
If you wish to change your email address, please reply email to us with "Change Contact" as the subject. Don't remove the above mentioned email address that was used to send this enewsletter.
Please note that we will not be able to give effect to the change or unsubscribe request if the email address that you enter in the reply email is different from the email address referenced above that was used by TCI to send this enewsletter.

To unsubscribe from future mailings, please email us with "Unsubscribe" as the subject to the address below.

» Unsubscribe

Tokyo Chemical Industrty Co., Ltd.
4-10-2 Nihonbashi-honcho, Chuo-ku,
Tokyo 103-0023

» TCIeNewsletter@TCIchemicals.com

» http://www.TCIchemicals.com