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Hofmann Elimination Reaction

 The Hofmann elimination is a reaction used to synthesize alkenes by the elimination of amine moiety from a quaternary alkyl ammonium salt. When alkyl amines are reacted with an alkyl halide forming an alkyl ammonium salt, the salt is treated with silver oxide or a strong base to afford an alkene via elimination of the amine moiety. When a linear alkyl amines are subjected to Hofmann elimination conditions, the less steric alkene is selectively provided due to Hofmann’s rules.



Reagents: alkyl amines, alkyl ammonium salts
Reactants: alkyl halides (e. g. iodomethane), silver oxide
Products: alkenes

Scheme:

Hofmann elimination Reaction

Original literature

Review literature