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Endo-α, an Enzyme that transfers a whole sugar

* 1 unit will hydrolyze 1μmol of Galβ1-3GalNAcα-pNP to Galβ1-3GalNAc and pNP per minute at pH 5.0 and 37 dgree-C.
* This product is not available in Canada, Americas and China.
Yamamoto et al. have recently purified and isolated endo-α-N-acetylgalactosaminidase (Endo-α) found in the culture fluid of Bifidobacterium longum.1a) Endo-α can recognize the structure of the Galβ1-3GalNAc disaccharide α-linked with a hydroxyl group. It releases Galβ1-3GalNAc by hydrolysis. When a compound possessing a hydroxyl group coexists as an acceptor, the released Galβ1-3GalNAc is transferred to the acceptor.1b)
Discovered by Yamamoto et al., Endo-α can transfer Galβ1-3GalNAc to various compounds such as Monosaccharides, peptides, and proteins, using core 1 contained in mucin-type oligosaccharide chains as a donor. As a tool for the enzymatic synthesis of glycoconjugates, it is expected that many applications for Endo-α will be found in a wide range of fields.
* This Endo-α was merchandised as the fruition of NEDO project.


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