Home > Featured Industries & Technical References > Quarterly Printed Magazine "TCIMAIL" > BackNumbers 2010 > Amination via Smiles Rearrangement

Amination via Smiles Rearrangement

No.143(August 2010)
2-Bromoisobutyramide  (1)
The Bucherer reaction is a well known method for the synthesis of amines from phenols using the reagent combination of NaHSO3 and NH3. 2-Bromoisobutyramide (1) is an effective alternate reagent for the synthesis of aromatic amines from phenols, via a one pot Smiles rearrangement2) under mild conditions. For example, phenol 2 was reacted with 1 under alkali conditions to give phenoxyether derivative 3. Then NaOH was added, and the mixture was heated to provide the rearrangement product 4. This product was hydrolyzed to give aniline derivative 5 in a 63% overall yield.1a) The obtained aniline derivatives are useful starting materials for medicines, functional materials, etc. In addition, the present one pot reaction sequence can be applied to thiophenols.1b)


The prices are subject to change without notice. Please confirm the newest price by our online catalog before placing an order.
In addition, sales products changes with areas. Please understand that a product is not available when the product details page is not displayed.