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A New Curcumin Analogue with Enhanced Antitumor Activities

No.168(January 2016)
B4823
GO-Y030  (1)
Curcumin (2) has chemopreventive and chemotherapeutic potentials against various types of cancers, but low bioavailability prevents its use in chemotherapeutic applications. GO-Y030 (1) is a new synthetic analogue of 2, developed by Shibata and Iwabuchi et al. to increase its potential and circumvent its low bioavailability. 1 has been reported that it shows a 30-fold greater suppression of tumor cell growth compared with 2.1) 1 has been reported that it inhibits signal transducers and activators of transcription 3 (STAT3)2a,b) and IKKβ kinase,2c) and suppresses tumor growth of cancer stem cells.2b) Additionally, the structure activity relationships of the antitumor 1 have been reported.3)

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