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WHI-P154
（CAS RN：211555-04-3 Produkt-Nr.：W0013）
Struktur
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| Synonym | 2-Bromo-4-[(6,7-dimethoxy-4-quinazolinyl)amino]phenol |
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Spezifikation
| Purity(HPLC) | min. 98.0 area% |
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| Melting point | 228.0 to 232.0 deg-C |
| Elemental analysis(Nitrogen) | 10.50 to 11.50 % |
Referenzdaten
| λmax | 335(MeOH)(lit.) |
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Referenzen
| Reaxys-RN | 8787580 |
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Antrag
WHI-P 154: A Potent Janus-Associated Kinase 3 (JAK3) Inhibitor
WHI-P 154 is a potent Janus-associated kinase 3 (JAK3) inhibitor that displays no activity at JAK1 or JAK2. JAK3 is a cytoplasmic protein tyrosine kinase that functions in the initiation of cytokine-triggered signal transduction by catalyzing the phosphorylation of signal transduction and activators of transcription (STAT). The phosphorylated SATAs are translocated to the nucleus to activate target genes. WHI-P 154 is cytotoxic human glioblastoma cells. Recent reports have indicated that JAK3 is expressed in lymphoid cells and is involved in the signaling of T cell functions. Therefore, the development of a selective JAK3 inhibitor has been shown to have a potential benefit in the treatment of autoimmune disorders. (The product is for research purpose only.)
References
- 4-(3'-Bromo-4'hydroxylphenyl)-amino-6,7-dimethoxyquinazoline: a novel quinazoline derivative with potent cytotoxic activity against human glioblastoma cells
- Inhibition of ALK enzymatic activity in T-cell lymphoma cells induces apoptosis and suppresses proliferation and STAT3 phosphorylation independently of Jak3
- The specificity of JAK3 kinase inhibitors
History ansehen
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