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Megestrol Acetate
(CAS RN:595-33-5 Product Number:M1949)

Structure

Megestrol Acetate
Synonym 17α-Acethoxy-6-methyl-4,6-pregnadiene-3,20-dione
Synonym 17α-Hydroxy-6-methyl-4,6-pregnadiene-3,20-dione 17-Acetate
Synonym Megestrol 17-Acetate

General Information

Product Number M1949

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Purity/Analysis Method >96.0%(HPLC)
Storage Temperature
M.F. / M.W. C24H32O4=384.52
CAS RN 595-33-5
Related CAS RN
MDL Number MFCD00056470
Packaging and Container
  • Product Details
  • Safety & Regulations
  • Reference & Application

Specification

Purity(HPLC) min. 96.0 area%
Melting point 213.0 to 220.0 deg-C
Specific rotation [a]20/D +9.0 to +13.0 deg(C=2, CHCl3)

References

Beilstein 8(4)2431
Reaxys-RN 1917291
PubChem SID 87560201
Merck Index(14) 5805
RTECS# TU4075000

GHS

Pictogram
Signal Word Warning
Hazard Statements
  • H351
  • :Suspected of causing cancer.
Precautionary Statements
  • P201
  • :Obtain special instructions before use.
  • P202
  • :Do not handle until all safety precautions have been read and understood.
  • P280
  • :Wear protective gloves, protective clothing, face protection.
  • P308+P313
  • :If exposed or concerned: Get medical advice or attention.
  • P405
  • :Store locked up.
  • P501
  • :Dispose of contents and container in accordance with local, regional, national regulations (e.g. US: 40 CFR Part 261, EU:91/156/EEC, JP: Waste Disposal and Cleaning Act, etc.).

Application

Megestrol Acetate: A Semi-Synthetic Progestational Agent

Megestrol acetate and medroxyprogesterone acetate [M1964], semi-synthetic progestational agents, are effective hormonal treatments for metastatic breast cancer in postmenopausal women. The antineoplastic effect may result from inhibition of pituitary gonadotropin production and resultant decrease in estrogen secretion. Recently, megestrol acetate is often used for the treatment of anorexia and cachexia. The precise mechanism is unknown at the present time. (The product is for research purpose only.)

References

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