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(R)-1-(3-Pyridylthiocarbamoyl)pyrrolidine-2-carboxylic Acid
(CAS RN:1443438-29-6 Product Number:P2298)


(R)-1-(3-Pyridylthiocarbamoyl)pyrrolidine-2-carboxylic Acid
Synonym (R)-PyT-C

General Information

Product Number P2298

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Purity/Analysis Method >98.0%(HPLC)(T)
Storage Temperature
M.F. / M.W. C11H13N3O2S=251.30
CAS RN 1443438-29-6
Related CAS RN
MDL Number
Packaging and Container
  • Product Details
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  • Reference & Application


Purity(HPLC) min. 98.0 area%
Purity(Neutralization titration) min. 98.0 %
Specific rotation [a]20/D +58.0 to +62.0 deg(C=1, 6mol/l HCl)


PubChem SID 354333476


Signal Word Warning
Hazard Statements
  • H315
  • :Causes skin irritation.
  • H319
  • :Causes serious eye irritation.
Precautionary Statements
  • P264
  • :Wash hands and face thoroughly after handling.
  • P280
  • :Wear protective gloves, eye protection.
  • P302+P352+P332+P313+P362+P364
  • :If on skin: Wash with plenty of soap and water. If skin irritation occurs: Get medical advice or attention. Take off contaminated clothing and wash it before reuse.
  • P305+P351+P338+P337+P313
  • :If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists: Get medical advice or attention.


Chiral Derivatization Reagent Possessing a Pyridylthiourea Structure

Typical Procedure:
A 10 mM 1 in acetonitrile (20 μL) is reacted at 60 °C for 60 min with chiral amines (10 μM) in the presence of 10 mM triphenylphosphine in acetonitrile (20 μL) and 10 mM 2,2'-dipyridyl disulfide in acetonitrile (20 μL). After removal of the solvent under a gentle nitrogen stream, the residues are re-dissolved in the initial mobile phase, and then an aliquot (2 μL) is subjected to UHPLC-ESI-MS/MS. The separations of the pair of diastereomers for chiral amines are performed by isocratic elution using water/acetonitrile containing 0.1% formic acid. The SRM chromatograms of each pair of diastereomers are obtained from the monitoring ion of m/z 137.0, derived from the MS transition of corresponding protonated-molecular ion, [M+H]+.


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