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Trichostatin A
(CAS RN:58880-19-6 Product Number:T2477)

Structure

Trichostatin A
Synonym [R-(E,E)]-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide
Synonym TSA

General Information

Product Number T2477

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Purity/Analysis Method >98.0%(HPLC)
Storage Temperature <0°C
M.F. / M.W. C17H22N2O3=302.37
CAS RN 58880-19-6
Related CAS RN
MDL Number MFCD03848392
Packaging and Container
  • Product Details
  • Safety & Regulations
  • Reference & Application

Specification

Purity(HPLC) min. 98.0 area%
Optical purity(LC) min. 95.0 ee%

Data of Reference

ee >95.0%(HPLC)

References

Reaxys-RN 2391788
PubChem SID 87560260
Merck Index(14) 9649
RTECS# MI5215000

GHS

Pictogram
Signal Word Warning
Hazard Statements
  • H302+H312+H332
  • :Harmful by inhalation, in contact with skin and if swallowed.
  • H315
  • :Causes skin irritation.
  • H319
  • :Causes serious eye irritation.
Precautionary Statements
  • P261
  • :Avoid breathing dust, fume, mist, vapors or spray.
  • P264
  • :Wash hands and face thoroughly after handling.
  • P270
  • :Do not eat, drink or smoke when using this product.
  • P271
  • :Use only outdoors or in a well-ventilated area.
  • P280
  • :Wear protective gloves, protective clothing, eye protection.
  • P301+P312+P330
  • :If swallowed: Call a poison center or doctor if you feel unwell. Rinse mouth.
  • P302+P352+P312+P362+P364
  • :If on skin: Wash with plenty of soap and water. Call a poison center or doctor if you feel unwell. Take off contaminated clothing and wash it before reuse.
  • P304+P340+P312
  • :If inhaled: Remove person to fresh air and keep comfortable for breathing. Call a poison center or doctor if you feel unwell.
  • P305+P351+P338+P337+P313
  • :If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists: Get medical advice or attention.
  • P501
  • :Dispose of contents and container in accordance with local, regional, national regulations (e.g. US: 40 CFR Part 261, EU:91/156/EEC, JP: Waste Disposal and Cleaning Act, etc.).

Application

Trichostatin A: A Potent Inhibitor of Histone Deacetylases (HDACs) with Potent Antitumor Activity

Trichostatin A(R-enantiomer) was originally developed as an antifungal antibiotic agent isolated from the metabolites of strains of Streptomyces hygroscopicus in 1976.1) From the 1980s onwards, it has been reported that trichostatin A is a potent inhibitor of histone deacetylases (HDACs) with potent antitumor activity.2-7) Trichostatin A causes the induction of cell differentiation and specific inhibition of the cell cycle in the G1 and G2 phases at the very low concentrations.For your reference, trichostatin A (R-enantiomer) is the more active enantiomer (eutomer) of (-)-trichostatin A (S-enantiomer) [T3633] (The product is for research purpose only.)

References

iPS cell generation boosting compounds

References

PubMed Literature

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