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Vinyl Bromide (ca. 12% in Tetrahydrofuran, ca. 1.0mol/L)
(CAS RN:593-60-2 Product Number:V0127)

Structure

Vinyl Bromide
Synonym Bromoethylene (ca. 12% in Tetrahydrofuran, ca. 1.0mol/L)

General Information

Product Number V0127

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Purity/Analysis Method
Storage Temperature 0-10°C
M.F. / M.W. C2H3Br=106.95
CAS RN 593-60-2
Related CAS RN
MDL Number MFCD00000183
Packaging and Container
  • Product Details
  • Safety & Regulations
  • Reference & Application

Specification

Concentration(HNMR) 11.5 to 12.5 w/w%

References

Reaxys-RN 1361370
PubChem SID 253661892

GHS

Pictogram
Signal Word Danger
Hazard Statements
  • H225
  • :Highly flammable liquid and vapor.
  • H302
  • :Harmful if swallowed.
  • H315
  • :Causes skin irritation.
  • H319
  • :Causes serious eye irritation.
  • H335
  • :May cause respiratory irritation.
  • H341
  • :Suspected of causing genetic defects.
  • H350
  • :May cause cancer.
  • H371
  • :May cause damage to Nervous System.
  • H372
  • :Causes damage to Liver, Nervous System, Kidney through prolonged or repeated exposure.
Precautionary Statements
  • P201
  • :Obtain special instructions before use.
  • P202
  • :Do not handle until all safety precautions have been read and understood.
  • P210
  • :Keep away from heat, sparks, open flames and hot surfaces. – No smoking.
  • P233
  • :Keep container tightly closed.
  • P240
  • :Ground and bond container and receiving equipment.
  • P241+P242+P243
  • :Use explosion-proof electrical, ventilating and lighting equipment. Use only non-sparking tools. Take precautionary measures against static discharge.
  • P260
  • :Do not breathe mist, vapors or spray.
  • P264
  • :Wash hands and face thoroughly after handling.
  • P270
  • :Do not eat, drink or smoke when using this product.
  • P271
  • :Use only outdoors or in a well-ventilated area.
  • P280
  • :Wear protective gloves, protective clothing, face protection.
  • P301+P312+P330
  • :If swallowed: Call a poison center or doctor if you feel unwell. Rinse mouth.
  • P302+P352+P332+P313+P362+P364
  • :If on skin: Wash with plenty of soap and water. If skin irritation occurs: Get medical advice or attention. Take off contaminated clothing and wash it before reuse.
  • P304+P340+P312
  • :If inhaled: Remove person to fresh air and keep comfortable for breathing. Call a poison center or doctor if you feel unwell.
  • P305+P351+P338+P337+P313
  • :If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists: Get medical advice or attention.
  • P308+P311
  • :If exposed or concerned: Call a poison center or doctor.
  • P403+P233
  • :Store in a well-ventilated place. Keep container tightly closed.
  • P405
  • :Store locked up.
  • P501
  • :Dispose of contents and container in accordance with local, regional, national regulations (e.g. US: 40 CFR Part 261, EU:91/156/EEC, JP: Waste Disposal and Cleaning Act, etc.).

Transport Information

UN Number 1993
Class 3
Packing Group II

Application

Enamide synthesis via cross-coupling

Application: To a screw-cap vial are added 1 (1.0 eq.),  vinyl bromide (1.0 M soln. in THF, 2.0 eq.), CuI (0.05 eq.), N,N’-dimethylethylenediamine (0.10 eq.), and K2CO3 (2.0 eq.). The vial is tightly sealed and heated to 80 °C to stir overnight. Upon completion of the reaction, the mixture is filtered through a pad of celite, rinsing with EtOAc, and solvent is removed in vacuo to afford a crude product. Purification of the resulting crude residue via silica gel flash chromatography (gradient elution: EtOAc in n-hexanes) affords 2 (58% yield) as a yellow solid.

References

PubMed Literature

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