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(CAS RN:125-84-8 Product Number:A1947)


Synonym 3-(4-Aminophenyl)-3-ethylpiperidine-2,6-dione

General Information

Product Number A1947

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Purity/Analysis Method >98.0%(HPLC)(T)
Storage Temperature
M.F. / M.W. C13H16N2O2=232.28
CAS RN 125-84-8
Related CAS RN
MDL Number MFCD00010122
Packaging and Container
  • Product Details
  • Safety & Regulations
  • Reference & Application


Appearance White to Light yellow powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(Nonaqueous Titration) min. 98.0 %
Melting point 150.0 to 154.0 deg-C
Solubility in Acetone very faint turbidity


Beilstein 22(5)13,297
Reaxys-RN 210656
PubChem SID 87558926
Merck Index(14) 440
RTECS# MA4026950


Signal Word Warning
Hazard Statements
  • H315
  • :Causes skin irritation.
  • H319
  • :Causes serious eye irritation.
Precautionary Statements
  • P264
  • :Wash hands and face thoroughly after handling.
  • P280
  • :Wear protective gloves, eye protection.
  • P302+P352+P332+P313+P362+P364
  • :If on skin: Wash with plenty of soap and water. If skin irritation occurs: Get medical advice or attention. Take off contaminated clothing and wash it before reuse.
  • P305+P351+P338+P337+P313
  • :If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists: Get medical advice or attention.


DL-Aminoglutethimide: A Potent but Nonselective Aromatase Inhibitor

DL-Aminoglutethimide is a first generation, and a potent but nonselective aromatase inhibitor. Aminoglutethimide inhibits the enzymatic side-chain cleavage of cholesterol [C0318] to pregnenolone [P0786], mediated through the binding of aminoglutethimide to cytochrome P 450, resulting in a decrease in the production of adrenal glucocorticoids, mineralocorticoids, estrogens, and androgens. Besides, aminoglutethimide-P450 complexes block enzymatic 11- and 18-hydroxylation steps required for the aromatization of androgens to estrogens. Aminoglutethimide is used for the treatment of Cushing’s syndrome, breast and prostate cancer. (The product is for research purpose only.)


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