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DL-Aminoglutethimide
(CAS RN:125-84-8 Product Number:A1947)

Structure

DL-Aminoglutethimide
Synonym 3-(4-Aminophenyl)-3-ethylpiperidine-2,6-dione

General Information

Product Number A1947

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Purity/Analysis Method >98.0%(HPLC)(T)
Storage Temperature
M.F. / M.W. C13H16N2O2=232.28
CAS RN 125-84-8
Related CAS RN
MDL Number MFCD00010122
Packaging and Container
  • Product Details
  • Safety & Regulations
  • Reference & Application

Specification

Appearance White to Light yellow powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(Nonaqueous Titration) min. 98.0 %
Melting point 150.0 to 154.0 deg-C
Solubility in Acetone very faint turbidity

References

Beilstein 22(5)13,297
Reaxys-RN 210656
PubChem SID 87558926
Merck Index(14) 440
RTECS# MA4026950

GHS

Pictogram
Signal Word Warning
Hazard Statements
  • H315
  • :Causes skin irritation.
  • H319
  • :Causes serious eye irritation.
Precautionary Statements
  • P264
  • :Wash hands and face thoroughly after handling.
  • P280
  • :Wear protective gloves, eye protection.
  • P302+P352+P332+P313+P362+P364
  • :If on skin: Wash with plenty of soap and water. If skin irritation occurs: Get medical advice or attention. Take off contaminated clothing and wash it before reuse.
  • P305+P351+P338+P337+P313
  • :If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists: Get medical advice or attention.

Application

DL-Aminoglutethimide: A Potent but Nonselective Aromatase Inhibitor

DL-Aminoglutethimide is a first generation, and a potent but nonselective aromatase inhibitor. Aminoglutethimide inhibits the enzymatic side-chain cleavage of cholesterol [C0318] to pregnenolone [P0786], mediated through the binding of aminoglutethimide to cytochrome P 450, resulting in a decrease in the production of adrenal glucocorticoids, mineralocorticoids, estrogens, and androgens. Besides, aminoglutethimide-P450 complexes block enzymatic 11- and 18-hydroxylation steps required for the aromatization of androgens to estrogens. Aminoglutethimide is used for the treatment of Cushing’s syndrome, breast and prostate cancer. (The product is for research purpose only.)

References

PubMed Literature

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