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ABT-751
(CAS RN:141430-65-1 Product Number:A3169)

Structure

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ABT-751
Synonym N-[2-[(4-Hydroxyphenyl)amino]pyridin-3-yl]-4-methoxybenzenesulfonamide

General Information

Product Number A3169

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Purity/Analysis Method >98.0%(HPLC)
Storage Temperature 0-10°C
M.F. / M.W. C18H17N3O4S=371.41
CAS RN 141430-65-1
Related CAS RN
MDL Number MFCD00910291
Packaging and Container
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Specification

Appearance White to Yellow to Orange powder to crystal
Purity(HPLC) min. 98.0 area%
Elemental analysis(Nitrogen) 10.70 to 11.90 %

References

Reaxys-RN 5455834
PubChem SID 354335530
RTECS# DB2734000

Application

ABT-751 (E7010): A Sulfonamide Tubulin Polymerization Inhibitor

ABT-751 (E7010) is a sulfonamide tubulin polymerization inhibitor, which is active against tumor cells. ABT-751 binds to the colchicine site on β-tubulin, and inhibits polymerization of microtubules that leads to a block in the cell cycle at the G2M phase, resulting in cellular apoptosis. (The product is for research purpose only.)

References

PubMed Literature

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