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Cladribine
(CAS RN:4291-63-8 Product Number:C2499)

Structure

Cladribine
Synonym CdA
Synonym 2-Chloro-2'-deoxyadenosine
Synonym 2-Chloro-9-(2-deoxy-β-D-arabinofuranosyl)adenine

General Information

Product Number C2499

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Purity/Analysis Method >98.0%(HPLC)
Storage Temperature 0-10°C
M.F. / M.W. C10H12ClN5O3=285.69
CAS RN 4291-63-8
Related CAS RN
MDL Number MFCD00153939
Packaging and Container
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  • Reference & Application

Specification

Appearance White to Almost white powder to crystal
Purity(HPLC) min. 98.0 area%
Elemental analysis(Nitrogen) 24.0 to 25.0 %

Data of Reference

mp 220°C(lit.)
λmax 265(EtOH aq.)(lit.)

References

Reaxys-RN 624220
PubChem SID 160871152
Merck Index(14) 2337
RTECS# AU7357560

Application

Studies on Chronic Lymphocytic Leukemia Cells

References

  • Deoxyadenosine analogs induce programmed cell death in chronic lymphocytic leukemia cells by damaging the DNA and by directly affecting the mitochondria
    • D. Genini, S. Adachi, Q. Chao, D. W. Rose, C. J. Carrera, H. B. Cottam, D. A. Carson, L. M. Leoni, Blood 2000, 96, 3537.
  • Induction of apoptotic cell death in chronic lymphocytic leukemia by 2-chloro-2'-deoxyadenosine and 9-β-D-arabinosyl-2-fluoroadenine
    • L. E. Robertson, S. Chubb, R. E. Meyn, M. Story, R. Ford, W. N. Hittelman, W. Plunkett, Blood 1993, 81, 143.
  • Specific toxicity of 2-chlorodeoxyadenosine toward resting and proliferating human lymphocytes
    • D. A. Carson, D. B. Wasson, R. Taetle, A. Yu, Blood 1983, 62, 737.

PubMed Literature

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