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2,4-Dibromo-6-[(E)-[[(1R,2R)-2-(isoindolin-2-yl)-1,2-diphenylethyl]imino]methyl]phenol
(CAS RN:1420042-07-4 Product Number:D5160)

Structure

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2,4-Dibromo-6-[(E)-[[(1R,2R)-2-(isoindolin-2-yl)-1,2-diphenylethyl]imino]methyl]phenol

General Information

Product Number D5160

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Purity/Analysis Method >93.0%(HPLC)
Storage Temperature <0°C
M.F. / M.W. C29H24Br2N2O=576.33
CAS RN 1420042-07-4
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Specification

Purity(HPLC) min. 93.0 area%

References

Reaxys-RN 28661479
PubChem SID 354334487

Application

Chiral Ligand for Asymmetric Iodocyclization

Experimental procedure: N-Ts alkenamide (0.1 mmol) and D5160-CuOAc complex (7.0 mg, 0.01 mmol) are dissolved in dichloromethane (1 mL) and toluene (3 mL). The mixture is stirred at room temperature for 10 min, and at -78 °C for 30 min. Then, NIS (24.6 mg, 0.11 mmol) and I2 (5.1 mg, 0.02 mmol) are added to the reaction mixture. After being stirred for 16-18 h, the reaction mixture is quenched with saturated Na2SO3 aq. and then the products are extracted with dichloromethane in 3 times. The collected organic layer is dried over Na2SO4. After removal of the solvent under reduced pressure, the residue is purified by silica-gel column chromatography (hexane:ethyl acetate = 3:1) to afford the iodocyclization product.

References

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