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Potassium Oxonate
(CAS RN:2207-75-2 Product Number:O0164)

Structure

Potassium Oxonate
Synonym Allantoxanic Acid Potassium Salt
Synonym Oxonic Acid Potassium Salt
Synonym Potassium Allantoxanate
Synonym Potassium 4,6-Dihydroxy-1,3,5-triazine-2-carboxylate

General Information

Product Number O0164

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Purity/Analysis Method >98.0%(HPLC)(T)
Storage Temperature
M.F. / M.W. C4H2KN3O4=195.18
CAS RN 2207-75-2
Related CAS RN 937-13-3
MDL Number MFCD00010565
Packaging and Container
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Specification

Purity(HPLC) min. 98.0 area%
Purity(Nonaqueous Titration) min. 98.0 %

References

Beilstein 24,451
Reaxys-RN 4049961
PubChem SID 87574167
RTECS# RR4580000

Application

Potassium Oxonate: An Inhibitor of Orotate Phosphoribosyltransferase (OPRT)

Potassium oxonate is an inhibitor of orotate phosphoribosyltransferase (OPRT) that is an enzyme involved in the biosynthesis of pyrimidine nucleotides and catalyzes the phosphorylation of 5-FU [F0151] to an active metabolite 5-fluorouridine-5'-monophosphate (FUMP). The gastrointestinal toxicity (GIT) of the oral administration of 5-FU is also caused by the phosphorylation by OPRT in the gut wall. Potassium oxonate selectively and competitively inhibits OPRT. As a result, 5-FU associated gastrointestinal toxic effects are reduced. Potassium oxonate is often used as combined agents to enhance the antitumor activity of fluoropyrimidines, such as S-1 (tegafur [F0635] a prodrug of 5-FU, gimeracil [C2243] and potassium oxonate at a molar ratio of 1:0.4:1). (The product is for research purpose only.)

References

Reagent for hyperuricemia (gout) model

References

PubMed Literature

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