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Pelitinib
(CAS RN:257933-82-7 Product Number:P2529)

Structure

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Pelitinib
Synonym (2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-dimethylamino-2-butenamide
Synonym EKB 569

General Information

Product Number P2529

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Purity/Analysis Method >97.0%(HPLC)
Storage Temperature <0°C
M.F. / M.W. C24H23ClFN5O2=467.93
CAS RN 257933-82-7
Related CAS RN
MDL Number MFCD09837868
Packaging and Container
  • Product Details
  • Safety & Regulations
  • Reference & Application

Specification

Purity(HPLC) min. 97.0 area%

Data of Reference

mp 198°C(lit.)

References

Reaxys-RN 9301287
PubChem SID 354335185

GHS

Pictogram
Signal Word Danger
Hazard Statements
  • H301+H311+H331
  • :Toxic by inhalation, in contact with skin and if swallowed.
  • H315
  • :Causes skin irritation.
  • H319
  • :Causes serious eye irritation.
Precautionary Statements
  • P261
  • :Avoid breathing dust, fume, mist, vapors or spray.
  • P264
  • :Wash hands and face thoroughly after handling.
  • P270
  • :Do not eat, drink or smoke when using this product.
  • P271
  • :Use only outdoors or in a well-ventilated area.
  • P280
  • :Wear protective gloves, protective clothing, eye protection.
  • P301+P310+P330
  • :If swallowed: Immediately call a poison center or doctor. Rinse mouth.
  • P302+P352+P312+P361+P364
  • :If on skin: Wash with plenty of soap and water. Call a poison center or doctor if you feel unwell. Take off immediately all contaminated clothing and wash it before reuse.
  • P304+P340+P311
  • :If inhaled: Remove person to fresh air and keep comfortable for breathing. Call a poison center or doctor.
  • P305+P351+P338+P337+P313
  • :If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists: Get medical advice or attention.
  • P403+P233
  • :Store in a well-ventilated place. Keep container tightly closed.
  • P405
  • :Store locked up.
  • P501
  • :Dispose of contents and container in accordance with local, regional, national regulations (e.g. US: 40 CFR Part 261, EU:91/156/EEC, JP: Waste Disposal and Cleaning Act, etc.).

Transport Information

UN Number 2811
Class 6.1
Packing Group III

Application

Pelitinib: An Irreversible Inhibitor of the Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase

Pelitinib (EKB-569) is an irreversible inhibitor of epidermal growth factor receptor (EGFR, also known as ErbB-1) tyrosine kinase. EGFR is the cell-surface receptor for members of the epidermal growth factors (EGFs) that play a central role in regulating cell division and death. EGFR tyrosine kinase is activated by binding of EGFs. This binding causes cell differentiation and proliferation. Therefore, pelitinib is often used for cancer research. For your reference, a related product [C3315] is a synthetic intermediate of pelitinib and neratinib (HKI-272). (The product is for research purpose only.)

References

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