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Gimeracil
(CAS RN:103766-25-2 Product Number:C2243)

Structure

Gimeracil
Synonym 5-Chloro-2,4-dihydroxypyridine
Synonym 5-Chloro-4-hydroxy-2(1H)-pyridinone
Synonym 5-Chloro-2,4-pyridinediol

General Information

Product Number C2243

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Purity/Analysis Method >98.0%(HPLC)(T)
Storage Temperature
M.F. / M.W. C5H4ClNO2=145.54
CAS RN 103766-25-2
Related CAS RN
MDL Number MFCD08458352
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Specification

Purity(HPLC) min. 98.0 area%
Purity(Neutralization titration) min. 98.0 %

Data of Reference

mp 274°C(dec.)(lit.)

References

Beilstein 21(4)2059
Reaxys-RN 119489
PubChem SID 87560206

Application

Gimeracil: A Dihydropyrimidine Dehydrogenase (DPD) Inhibitor

Gimeracil (5-chloro-2,4-dihydroxypyridine or CDHP) is a potent inhibitor of dihydropyrimidine dehydrogenase (DPD) which is an enzyme that is involved in pyrimidine degradation. Gimeracil itself does not influence cell proliferation, whereas it reversibly inhibits 5-FU [F0151] degradation and enhanced 5-FU cytotoxicity in tumor cell lines. Gimeracil is often used as combined agents to enhance the antitumor activity of fluoropyrimidines, such as S-1 (tegafur [F0635] a prodrug of 5-FU, gimeracil and potassium oxonate [O0164] at a molar ratio of 1:0.4:1). (The product is for research purpose only.)

References

PubMed Literature

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