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4-[(6,7-Dimethoxyquinolin-4-yl)oxy]aniline
(CAS RN:190728-25-7 Product Number:D5070)

Structure

4-[(6,7-Dimethoxyquinolin-4-yl)oxy]aniline
Synonym 4-(4-Aminophenoxy)-6,7-dimethoxyquinoline

General Information

Product Number D5070

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Purity/Analysis Method
Storage Temperature
M.F. / M.W. C17H16N2O3=296.33
CAS RN 190728-25-7
Related CAS RN
MDL Number MFCD19685633
Packaging and Container
  • Product Details
  • Safety & Regulations
  • Reference & Application

Specification

Purity(HPLC) min. 98.0 area%
Purity(Nonaqueous Titration) min. 95.0 %
Melting point 211.0 to 215.0 deg-C

Data of Reference

mp 214°C(lit.)

References

Reaxys-RN 1490304
PubChem SID 354334606

GHS

Pictogram
Signal Word Warning
Hazard Statements
  • H315
  • :Causes skin irritation.
  • H319
  • :Causes serious eye irritation.
Precautionary Statements
  • P264
  • :Wash hands and face thoroughly after handling.
  • P280
  • :Wear protective gloves, eye protection.
  • P302+P352+P332+P313+P362+P364
  • :If on skin: Wash with plenty of soap and water. If skin irritation occurs: Get medical advice or attention. Take off contaminated clothing and wash it before reuse.
  • P305+P351+P338+P337+P313
  • :If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists: Get medical advice or attention.

Application

A Synthetic Intermediate of VEGFR-2 Tyrosine Kinase Inhibitors and PDGFR Tyrosine Kinase Inhibitors

This reagent has been used for the synthesis of vascular endothelial growth factor receptor-2 (VEGFR-2) tyrosine kinase inhibitors such as cabozantinib [CAS: 849217-68-1],1-3) and platelet-derived growth factor receptor (PDGFR) tyrosine kinase inhibitors.4,5)

References

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