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Etoposide
(CAS RN:33419-42-0 Product Number:E0675)

Structure

Etoposide
Synonym 4'-Demethylepipodophyllotoxin 9-(4,6-O-Ethylidene-β-D-glucopyranoside)

General Information

Product Number E0675

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Purity/Analysis Method >98.0%(HPLC)
Storage Temperature
M.F. / M.W. C29H32O13=588.56
CAS RN 33419-42-0
Related CAS RN
MDL Number
Packaging and Container
  • Product Details
  • Safety & Regulations
  • Reference & Application

Specification

Purity(HPLC) min. 98.0 area%
Water max. 7.0 %

Data of Reference

mp 251°C(lit.)

References

Reaxys-RN 365969
PubChem SID 87558799
Merck Index(14) 3886
RTECS# KC0190000

GHS

Pictogram
Signal Word Danger
Hazard Statements
  • H302
  • :Harmful if swallowed.
  • H340
  • :May cause genetic defects.
  • H350
  • :May cause cancer.
  • H360
  • :May damage fertility or the unborn child.
  • H362
  • :May cause harm to breast-fed children.
  • H371
  • :May cause damage to organs.
  • H372
  • :Causes damage to Bone Marrow, Lung through prolonged or repeated exposure.
Precautionary Statements
  • P201
  • :Obtain special instructions before use.
  • P202
  • :Do not handle until all safety precautions have been read and understood.
  • P260
  • :Do not breathe dust, fume, mist, vapors or spray.
  • P263
  • :Avoid contact during pregnancy or while nursing.
  • P264
  • :Wash hands and face thoroughly after handling.
  • P270
  • :Do not eat, drink or smoke when using this product.
  • P280
  • :Wear protective gloves, protective clothing, face protection.
  • P301+P312+P330
  • :If swallowed: Call a poison center or doctor if you feel unwell. Rinse mouth.
  • P308+P311
  • :If exposed or concerned: Call a poison center or doctor.
  • P405
  • :Store locked up.
  • P501
  • :Dispose of contents and container in accordance with local, regional, national regulations (e.g. US: 40 CFR Part 261, EU:91/156/EEC, JP: Waste Disposal and Cleaning Act, etc.).

Application

Etoposide: A Topoisomerase-II Inhibitor

Etoposide (VP 16) is a semisynthetic antitumor alkaloid which is synthesized form podophyllotoxin [P1771] , a toxin found in the American Mayapple. Etoposide interferes with DNA synthesis by inhibiting the enzyme topoisomerase-II. In order to prevent and correct of topological problems caused by the DNA double helix, topoisomerase-II catalyzes the relaxation of negatively supercoiled DNA, the knotting and unknotting DNA and the linking complementary rings of single-stranded DNA into double-stranded rings. Then the inhibition action leads to cell cycle arrest at G2/M, apoptosis or cell death. Bacterial type II topoisomerases (DNA gyrase and Topoisomerase-IV) are the targets of quinolone antibiotics.

References

PubMed Literature

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