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2-Hydroxypyridine N-Oxide
(CAS RN:13161-30-3 Product Number:H0672)


2-Hydroxypyridine N-Oxide
Synonym HOPO
Synonym 1-Hydroxy-2-pyridone
Synonym 2-Pyridinol N-Oxide

General Information

Product Number H0672

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Purity/Analysis Method >98.0%(T)
Storage Temperature
M.F. / M.W. C5H5NO2=111.10
CAS RN 13161-30-3
Related CAS RN
MDL Number MFCD00006195
Packaging and Container
  • Product Details
  • Safety & Regulations
  • Reference & Application


Purity(Neutralization titration) min. 98.0 %
Melting point 149.0 to 152.0 deg-C
Solubility in hot Methanol very faint turbidity


Beilstein 21(3/4)3381
Reaxys-RN 1422545
PubChem SID 87571045


Signal Word Warning
Hazard Statements
  • H315
  • :Causes skin irritation.
  • H319
  • :Causes serious eye irritation.
Precautionary Statements
  • P264
  • :Wash hands and face thoroughly after handling.
  • P280
  • :Wear protective gloves, eye protection.
  • P302+P352+P332+P313+P362+P364
  • :If on skin: Wash with plenty of soap and water. If skin irritation occurs: Get medical advice or attention. Take off contaminated clothing and wash it before reuse.
  • P305+P351+P338+P337+P313
  • :If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists: Get medical advice or attention.


An Efficient Additive for Condensation Reactions

Experimental procedure: EDC·HCl (102 mg, 0.53 mmol) is added in one portion to 1 (200 mg, 0.35 mmol), (S)-1-phenylethylamine (64 mg, 0.53 mmol) and 2-hydroxy-pyridine N-oxide (47 mg, 0.42 mmol) dissolved in dichloromethane (2 mL). The resulting solution is stirred at rt for 60 min. More EDC·HCl (50 mg) is added and the mixture is stirred at rt for 15 min more. The solution is washed with a 10% aqueous citric acid solution, water and brine then purified by flash chromatography eluting with 0 to 10% methanol in ethyl acetate. The solvent is evaporated to dryness to afford 2 (185 mg, 98%) as a white solid.


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