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2-Methyl-7-[phenyl(phenylamino)methyl]-8-quinolinol
(CAS RN:6964-62-1 Product Number:M2390)

Structure

2-Methyl-7-[phenyl(phenylamino)methyl]-8-quinolinol
Synonym 8-Hydroxy-2-methyl-7-[phenyl(phenylamino)methyl]quinoline
Synonym NSC 66811

General Information

Product Number M2390

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Purity/Analysis Method >98.0%(GC)
Storage Temperature 0-10°C
M.F. / M.W. C23H20N2O=340.43
CAS RN 6964-62-1
Related CAS RN
MDL Number MFCD08823776
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Specification

Purity(GC) min. 98.0 %
Purity(Nonaqueous Titration) min. 96.0 %
Melting point 143.0 to 147.0 deg-C

Data of Reference

λmax 250(EtOH)(lit.)

References

Reaxys-RN 303275
PubChem SID 354335381

Application

NSC 66811: An Inhibitor of MDM2-P53 Protein-Protein Interaction

NSC 66811 is an inhibitor of the murine double minute 2 (MDM2)-p53 protein-protein interaction. MDM2 protein is an oncogenic one, and p53 is a tumor suppressor protein. Reportedly, the p53 is inactivated in many cancer cells through mutations or by its interaction with MDM2 protein. Therefore, recently it is considered that blocking the MDM2-p53 interaction is a novel anticancer strategy. (The product is for research purpose only.)

References

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