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Tropisetron Hydrochloride
(CAS RN:105826-92-4 Product Number:T2743)


Tropisetron Hydrochloride
Synonym (3-endo)-8-Methyl-8-azabicyclo[3.2.1]oct-3-yl 1H-Indole-3-carboxylate Hydrochloride

General Information

Product Number T2743

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Purity/Analysis Method >98.0%(HPLC)(T)
Storage Temperature 0-10°C
M.F. / M.W. C17H20N2O2·HCl=320.82
CAS RN 105826-92-4
Related CAS RN 89565-68-4
MDL Number MFCD00210221
Packaging and Container
  • Product Details
  • Safety & Regulations
  • Reference & Application


Purity(HPLC) min. 98.0 area%
Purity(Nonaqueous Titration) min. 98.0 %

Data of Reference

mp 285°C(dec.)(lit.)


Reaxys-RN 8883131
PubChem SID 160871173
Merck Index(14) 9783
RTECS# NL6012520


Signal Word Danger
Hazard Statements
  • H301
  • :Toxic if swallowed.
Precautionary Statements
  • P264
  • :Wash hands and face thoroughly after handling.
  • P270
  • :Do not eat, drink or smoke when using this product.
  • P301+P310+P330
  • :If swallowed: Immediately call a poison center or doctor. Rinse mouth.
  • P405
  • :Store locked up.
  • P501
  • :Dispose of contents and container in accordance with local, regional, national regulations (e.g. US: 40 CFR Part 261, EU:91/156/EEC, JP: Waste Disposal and Cleaning Act, etc.).

Transport Information

UN Number 2811
Class 6.1
Packing Group III


Tropisetron hydrochloride: A Selective Competitive 5-HT3 Receptor Antagonist

Tropisetron hydrochloride is a selective competitive antagonist of 5-hydroxytryptamine 3 (5-HT3) receptor which is a subclass of serotonin receptors. 5-HT3 receptors are located peripherally on vagal nerve terminals and centrally in the chemoreceptor trigger zone (CTZ) of the area postrema, known as the emetic center of the brain. Therefore, tropisetron is used for the prevention of chemotherapy-induced nausea and vomiting.1,2) Tropisetron is mainly metabolized by cytochrome P450 (CYP) 2D6.3) In 2000’s, it has been reported that tropisetron is also a selective partial agonist at α7 nicotinic acetylcholine receptors (α7nAChRs). 4,5) (The product is for research purpose only.)


PubMed Literature

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