Home >   Products   >  Advanced Search

Tropisetron Hydrochloride
(CAS RN:105826-92-4 Product Number:T2743)

Structure

Tropisetron Hydrochloride
Synonym (3-endo)-8-Methyl-8-azabicyclo[3.2.1]oct-3-yl 1H-Indole-3-carboxylate Hydrochloride

General Information

Product Number T2743

* Please contact our distributor or us if you would like to know purchase prices in Australia that include freight cost, customs charge and other charges to the destination.
* To send your quote request for bulk quantities, please click on the "Request Bulk Quotation" button. Please note that we cannot offer bulk quantities for some products.
* TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.

Purity/Analysis Method >98.0%(HPLC)(T)
Storage Temperature 0-10°C
M.F. / M.W. C17H20N2O2·HCl=320.82
CAS RN 105826-92-4
Related CAS RN 89565-68-4
MDL Number MFCD00210221
Packaging and Container
  • Product Details
  • Safety & Regulations
  • Reference & Application

Specification

Purity(HPLC) min. 98.0 area%
Purity(Nonaqueous Titration) min. 98.0 %

Data of Reference

mp 285°C(dec.)(lit.)

References

Reaxys-RN 8883131
PubChem SID 160871173
Merck Index(14) 9783
RTECS# NL6012520

GHS

Pictogram
Signal Word Danger
Hazard Statements
  • H301
  • :Toxic if swallowed.
Precautionary Statements
  • P264
  • :Wash hands and face thoroughly after handling.
  • P270
  • :Do not eat, drink or smoke when using this product.
  • P301+P310+P330
  • :If swallowed: Immediately call a poison center or doctor. Rinse mouth.
  • P405
  • :Store locked up.
  • P501
  • :Dispose of contents and container in accordance with local, regional, national regulations (e.g. US: 40 CFR Part 261, EU:91/156/EEC, JP: Waste Disposal and Cleaning Act, etc.).

Transport Information

UN Number 2811
Class 6.1
Packing Group III

Application

Tropisetron hydrochloride: A Selective Competitive 5-HT3 Receptor Antagonist

Tropisetron hydrochloride is a selective competitive antagonist of 5-hydroxytryptamine 3 (5-HT3) receptor which is a subclass of serotonin receptors. 5-HT3 receptors are located peripherally on vagal nerve terminals and centrally in the chemoreceptor trigger zone (CTZ) of the area postrema, known as the emetic center of the brain. Therefore, tropisetron is used for the prevention of chemotherapy-induced nausea and vomiting.1,2) Tropisetron is mainly metabolized by cytochrome P450 (CYP) 2D6.3) In 2000’s, it has been reported that tropisetron is also a selective partial agonist at α7 nicotinic acetylcholine receptors (α7nAChRs). 4,5) (The product is for research purpose only.)

References

PubMed Literature

Page Top