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Teniposide
(CAS RN:29767-20-2 Product Number:T3109)

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Teniposide

General Information

Product Number T3109

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Purity/Analysis Method >98.0%(HPLC)
Storage Temperature -20°C
M.F. / M.W. C32H32O13S=656.66
CAS RN 29767-20-2
Related CAS RN
MDL Number MFCD00866516
Packaging and Container
  • Product Details
  • Safety & Regulations
  • Reference & Application

Specification

Purity(HPLC) min. 98.0 area%
Specific rotation [a]20/D -107.0 to -115.0 deg(C=1, CHCl3:MeOH=9:1)

Data of Reference

λmax 283(MeOH)(lit.)

References

Reaxys-RN 7108452
PubChem SID 253662241
Merck Index(14) 9145
RTECS# KC0180000

GHS

Pictogram
Signal Word Danger
Hazard Statements
  • H341
  • :Suspected of causing genetic defects.
  • H350
  • :May cause cancer.
  • H361
  • :Suspected of damaging fertility or the unborn child.
  • H371
  • :May cause damage to Bone Marrow.
  • H372
  • :Causes damage to Bone Marrow, Digestive Tract through prolonged or repeated exposure.
Precautionary Statements
  • P201
  • :Obtain special instructions before use.
  • P202
  • :Do not handle until all safety precautions have been read and understood.
  • P260
  • :Do not breathe dust, fume, mist, vapors or spray.
  • P264
  • :Wash hands and face thoroughly after handling.
  • P270
  • :Do not eat, drink or smoke when using this product.
  • P280
  • :Wear protective gloves, protective clothing, face protection.
  • P308+P311
  • :If exposed or concerned: Call a poison center or doctor.
  • P405
  • :Store locked up.
  • P501
  • :Dispose of contents and container in accordance with local, regional, national regulations (e.g. US: 40 CFR Part 261, EU:91/156/EEC, JP: Waste Disposal and Cleaning Act, etc.).

Application

Teniposide: An Inhibitor of Topoisomerase II

Teniposide (VM26) and etoposide (VP16-213) [E0675] are semisynthetic derivatives of podophyllotoxin [P1771], an alkaloid. Teniposide and teniposide are an inhibitor of topoisomerase II such as doxorubicin [D4193], daunorubicin [D4532]. Topoisomerase II is an enzyme essential for DNA replication, chromosome condensation and chromosome segregation. Topoisomerase II inhibitors are potent inducers of double strand breaks in DNA, and can cause arrest in the cell cycle at the G2 stage. Therefore, topoisomerase II inhibitors are the most widely used anti-cancer agents. Teniposide is used for the treatment of acute lymphocytic leukemia (ALL). (The product is for research purpose only.)

References

PubMed Literature

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