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Atropine
(CAS RN:51-55-8 Product Number:A0754)

Structure

Atropine
Synonym (±)-Hyoscyamine

General Information

Product Number A0754

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Purity/Analysis Method >99.0%(T)
Storage Temperature
M.F. / M.W. C17H23NO3=289.38
CAS RN 51-55-8
Related CAS RN
MDL Number MFCD00022622
Packaging and Container
  • Product Details
  • Safety & Regulations

Specification

Purity(HPLC) min. 98.0 area%
Purity(Nonaqueous Titration) min. 99.0 %
Melting point 114.0 to 118.0 deg-C
Solubility in Methanol almost transparency

References

Beilstein 21(3/4)183
Reaxys-RN 91256
PubChem SID 87562295
Merck Index(14) 875
RTECS# CK0700000
EC Number 200-104-8

GHS

Pictogram
Signal Word Danger
Hazard Statements
  • H300+H330
  • :Fatal by inhalation and if swallowed.
Precautionary Statements
  • P260
  • :Do not breathe dust, fume, mist, vapours or spray.
  • P270
  • :Do not eat, drink or smoke when using this product.
  • P284
  • :Wear respiratory protection.
  • P301+P310+P330
  • :IF SWALLOWED: Immediately call a POISON CENTER or doctor. Rinse mouth.
  • P304+P340+P310
  • :IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER or doctor.
  • P403+P233
  • :Store in a well-ventilated place. Keep container tightly closed.

Transport Information

UN Number 1544
Class 6.1
Packing Group III
HS Number 2939790090

Application

Atropine: A Nonselective Muscarinic Acetylcholinergic Receptors Antagonist

Atropine, a tropane alkaloid, is a free base of its sulfate [A0550] which was first extracted from the root of belladonna (Atropa belladonna) in 1830s. Atropine is a enantiomeric mixture of (R,S)-hyoscyamine (dl-hyoscyamine), racemization occurring during the extraction procedure, whereas only (S)-hyoscyamine (l-hyoscyamine) is the active isomer.
Atropine is a competitive antagonist of muscarine-like actions of acetylcholine and is therefore classified as an antimuscarinic agent. Atropine does not distinguish among the M1, M2, and M3 subgroups of muscarinic receptors. Atropine inhibits the action of acetylcholine at postganglionic nerve endings, thus affecting receptors of the exocrine glands, smooth muscle, cardiac muscle and the central nervous system. (The product is for research purpose only.)

References

PubMed Literature

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