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9-β-D-Arabinofuranosylguanine Hydrate
(CAS RN:38819-10-2 Product Number:A2739)

Structure

9-beta-D-Arabinofuranosylguanine
Synonym Ara-G Hydrate
Synonym Guanine 9-β-D-Arabinofuranoside Hydrate

General Information

Product Number A2739

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Purity/Analysis Method >98.0%(HPLC)
Storage Temperature 0-10°C
M.F. / M.W. C10H13N5O5·xH2O=283.24(as Anhydrous)
CAS RN 38819-10-2
Related CAS RN
MDL Number MFCD00065486
Packaging and Container
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Specification

Purity(HPLC) min. 98.0 area%
Elemental analysis(Nitrogen) 24.00% to 25.50% (calcd.on anh.substance)
Water 4.0 to 7.0 %

Data of Reference

mp 225°C(lit.)
λmax 252(lit.)

References

Reaxys-RN 1225954
PubChem SID 253662300
RTECS# MF8301000

Transport Information

HS Number 2934999090

Application

Ara-G: An Inhibitor of DNA Replication in T-Leukemic Cells

Arabinosylguanine (ara-G) is triphosphorylated by multiple kinases intracellularly to the active nucleotide, ara-GTP, which inhibits the DNA replication in T-leukemic cells. Ara-G is used for the treatment of T-cell acute lymphoblastic leukemia (T-ALL) or T-cell lymphoblastic lymphoma (T-LBL). From the 2000s, nelarabine (the 6-methoxy pro-drug of ara-G) have been introduced and used for the treatment of T-All and T-LBL. In organic synthesis, ara-G is used as an intermediate for the synthesis of guanosine analogs. (The product is for research purpose only.)

References

PubMed Literature

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