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BAY 11-7085
(CAS RN:196309-76-9 Product Number:B4845)

Structure

BAY 11-7085
Synonym (E)-3-(4-tert-Butylphenylsulfonyl)acrylonitrile

General Information

Product Number B4845

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Purity/Analysis Method >97.0%(N)
Storage Temperature 0-10°C
M.F. / M.W. C13H15NO2S=249.33
CAS RN 196309-76-9
Related CAS RN
MDL Number MFCD01862602
Packaging and Container
  • Product Details
  • Safety & Regulations

Specification

Purity(HPLC) min. 98.0 area%
Purity(with Total Nitrogen) min. 97.0 %
Melting point 82.0 to 86.0 deg-C

References

Reaxys-RN 9999499
PubChem SID 354333080
RTECS# UD1312500

GHS

Pictogram
Signal Word Warning
Hazard Statements
  • H302
  • :Harmful if swallowed.
  • H315
  • :Causes skin irritation.
  • H319
  • :Causes serious eye irritation.
Precautionary Statements
  • P264
  • :Wash hands and face thoroughly after handling.
  • P270
  • :Do not eat, drink or smoke when using this product.
  • P280
  • :Wear protective gloves, eye protection.
  • P301+P312+P330
  • :IF SWALLOWED: Call a POISON CENTER or doctor if you feel unwell. Rinse mouth.
  • P302+P352+P332+P313+P362+P364
  • :IF ON SKIN: Wash with plenty of water. If skin irritation occurs: Get medical advice or attention. Take off contaminated clothing and wash it before reuse.
  • P305+P351+P338+P337+P313
  • :IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists: Get medical advice or attention.

Transport Information

HS Number 2931399090

Application

Bay 11-7085: An Inhibitor of NFκB and IκBα Phosphorylation

Bay 11-7085 and Bay 11-7082 [T2846] are inhibitors of nuclear factor-κB (NFκB) and phosphorylation of IκBα. They have been shown to inhibit cell proliferation and induce apoptosis of a variety of cells. NFκB is a protein complex controls transcription of DNA and inflammatory cytokine production. Researches demonstrate that inhibition of NFκB can suppress the angiogenic potential and metastasis of cancer cells. IκBα is one member of a family of cellular proteins that function to inhibit the NF-κB transcription factor. In addition, they have anti-inflammatory activity.

References

PubMed Literature

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