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Citalopram Hydrobromide
(CAS RN:59729-32-7 Product Number:C2370)

Structure

Citalopram Hydrobromide
Synonym 1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile Hydrobromide

General Information

Product Number C2370

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Purity/Analysis Method >98.0%(HPLC)(T)
Storage Temperature
M.F. / M.W. C20H21FN2O·HBr=405.31
CAS RN 59729-32-7
Related CAS RN 59729-33-8
MDL Number MFCD02101306
Packaging and Container
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Specification

Purity(HPLC) min. 98.0 area%
Purity(Nonaqueous Titration) min. 98.0 %

References

Reaxys-RN 5368282
PubChem SID 125307911
Merck Index(14) 2318
RTECS# NP6406750
EC Number 261-890-6

Transport Information

HS Number 2932990090

Application

Citalopram Hydrobromide: A Selective Serotonin Reuptake Inhibitor (SSRI)

Citalopram hydrobromide is a selective serotonin reuptake inhibitor (SSRI). It is a racemic bicyclic phthalane derivative consisting of a 1:1 mixture of the R(-)- and S(+)[E0958] -enantiomers. The mechanism of action of citalopram HBr as an antidepressant is presumed to be linked to potentiation of serotonergic activity in the central nervous system (CNS) resulting from its inhibition of CNS neuronal reuptake of serotonin (5-HT) [S0370].  In vitro and in vivo studies suggest that citalopram a highly SSRI with minimal effects on norepinephrine (NA) [A0906] and dopamine (DA) [A0305] neural reuptake. In additon, citalopram has no antagonistic activity towards DA, NA, 5-HT, histamine [H0146, H0147], GABA [A0282], acetylcholine [A0084, chloride], and morphine receptors. Although, the inhibition primarily due to the active S(+)-enantiomer, it is reported that the R(-)-enantiomer counteracts the activity of the S(+)[E0958] -enantiomer. (The product is for research purpose only.)

References

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