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3-(3,4-Dihydroxyphenyl)-2-methyl-L-alanine Sesquihydrate
(CAS RN:555-30-6 Product Number:D1817)


Synonym Methyldopa Sesquihydrate
Synonym α-Methyl-L-DOPA Sesquihydrate

General Information

Product Number D1817

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Purity/Analysis Method >98.0%(HPLC)(T)
Storage Temperature
M.F. / M.W. C10H13NO4·11/2H2O=211.22(as Anhydrous)
CAS RN 555-30-6
Related CAS RN 41372-08-1
MDL Number MFCD00004186
Packaging and Container
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Purity(HPLC) min. 98.0 area%
Purity(Nonaqueous Titration) min. 98.0 %(calcd.on anh.substance)
Specific rotation [a]20/D -12.5 to -14.5 deg(C=1, H2O)
Solubility in hot Water almost transparency
Water 10.0 to 12.0 %


Reaxys-RN 2807721
PubChem SID 87568286
Merck Index(14) 6055
RTECS# AY5950000
EC Number 209-089-2

Transport Information

HS Number 2922500090


Methyldopa: An Aromatic-Amino Acid Decarboxylase Inhibitor

Methyldopa is an aromatic-amino acid decarboxylase inhibitor. It inhibits the decarboxylation of L-DOPA [D0600], thereby interfering with the formation of dopamine [A0305 (HCl salt)], a precursor of L-norepinephrine [A0906 (bitartrate)]. Methyldopa is an effective anti-hypertensive agent that reduces both supine and standing blood pressure. At first, the anti-hypertensive activity was believed to be related with the inhibition. Nowadays, methyldopa is metabolized to α-methylnorepinephrine and this compound is thought to stimulate central nerve α-adrenergic receptors, producing a decrease in peripheral sympathetic outflow, and resulting in decreasing blood pressure. (The product is for research purpose only.)


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